C
Charles C. Ouimet
Researcher at Florida State University
Publications - 49
Citations - 6785
Charles C. Ouimet is an academic researcher from Florida State University. The author has contributed to research in topics: Dendritic spine & Nucleus accumbens. The author has an hindex of 36, co-authored 49 publications receiving 6604 citations. Previous affiliations of Charles C. Ouimet include Brown University & Yale University.
Papers
More filters
Journal ArticleDOI
A 38,000-dalton membrane protein (p38) present in synaptic vesicles.
TL;DR: Solubilization experiments, as well as phase separation experiments using Triton X-114, indicated that p38 is an integral membrane protein.
Journal ArticleDOI
DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. III. Immunocytochemical localization
TL;DR: Immunocytochemical studies indicate that DARPP-32, is present in the subclass of dopaminoceptive neurons containing D-1 receptors (dopamine receptors coupled to adenylate cyclase) and may be an effective marker for certain of the actions of dopamine that are mediated through cAMP and its associated protein kinase.
Journal ArticleDOI
DARPP-32: Regulator of the Efficacy of Dopaminergic Neurotransmission
Allen A. Fienberg,Noboru Hiroi,Paul G. Mermelstein,Wen Jie Song,Gretchen L. Snyder,Akinori Nishi,A. Cheramy,James P. O'Callaghan,D. B. Miller,Douglas G. Cole,R. Corbett,Colin N. Haile,Donald C. Cooper,S. P. Onn,Anthony A. Grace,Charles C. Ouimet,F. J. White,Steven E. Hyman,D. J. Surmeier,Jean-Antoine Girault,Eric J. Nestler,Paul Greengard +21 more
TL;DR: The results show that DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission and is converted in response to dopamine into a potent protein phosphatase inhibitor.
Journal ArticleDOI
Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5
James A. Bibb,Jingshan Chen,Jane R. Taylor,Per Svenningsson,Akinori Nishi,Akinori Nishi,Gretchen L. Snyder,Zhen Yan,Zhen Yan,Zachary K. Sagawa,Charles C. Ouimet,Angus C. Nairn,Eric J. Nestler,Eric J. Nestler,Paul Greengard +14 more
TL;DR: The results suggest that changes in Cdk5 levels mediated by ΔFosB, and resulting alterations in signalling involving D1 dopamine receptors, contribute to adaptive changes in the brain related to cocaine addiction.
Journal ArticleDOI
Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines
TL;DR: It is proposed that spinophilin represents a novel targeting subunit for PP1, which directs the enzyme to those substrates in the dendritic spine compartment, e.g., neurotransmitter receptors, which mediate the regulation of synaptic function by PP1.