R
Reinhard Jahn
Researcher at Max Planck Society
Publications - 404
Citations - 58546
Reinhard Jahn is an academic researcher from Max Planck Society. The author has contributed to research in topics: Synaptic vesicle & Exocytosis. The author has an hindex of 123, co-authored 387 publications receiving 54954 citations. Previous affiliations of Reinhard Jahn include French Institute of Health and Medical Research & Rockefeller University.
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Journal ArticleDOI
SNAREs--engines for membrane fusion.
TL;DR: A fascinating picture of these robust nanomachines is emerging, which seems to be conserved and adaptable for fusion reactions as diverse as those involved in cell growth, membrane repair, cytokinesis and synaptic transmission.
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Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
TL;DR: The X-ray crystal structure of a core synaptic fusion complex containing syntaxin-1A, synaptobrevin-II and SNAP-25B reveals a highly twisted and parallel four-helix bundle that differs from the bundles described for the haemagglutinin and HIV/SIV gp41 membrane-fusion proteins.
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Molecular Anatomy of a Trafficking Organelle
Shigeo Takamori,Matthew Holt,Katinka Stenius,Edward A. Lemke,Mads Grønborg,Dietmar Riedel,Henning Urlaub,Stephan Schenck,Britta Brügger,Philippe Ringler,Shirley A. Müller,Burkhard Rammner,Frauke Gräter,Jochen S. Hub,Bert L. de Groot,Gottfried Mieskes,Yoshinori Moriyama,Jürgen Klingauf,Helmut Grubmüller,John E. Heuser,Felix T. Wieland,Reinhard Jahn +21 more
TL;DR: A model has been constructed that integrates all quantitative data and includes structural models of abundant proteins and, with the exception of the V-ATPase, contains numerous copies of proteins essential for membrane traffic and neurotransmitter uptake.
Journal ArticleDOI
Membrane Fusion and Exocytosis
Reinhard Jahn,Thomas C. Südhof +1 more
TL;DR: Fusion of intracellular membranes in eukaryotic cells involves several protein families including SNAREs, Rab proteins, and Sec1/Munc-18 related proteins (SM-proteins).
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Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25
Juan Blasi,Juan Blasi,Edwin R. Chapman,E. Link,Thomas Binz,S. Yamasaki,Pietro De Camilli,Thomas C. Südhof,Heiner Niemann,Reinhard Jahn +9 more
TL;DR: It is demonstrated that BoNT/A acts as a zinc-dependent protease that selectively cleaves SNAP-25, a second component of the putative fusion complex mediating synaptic vesicle exocytosis is targeted by a clostridial neurotoxin.