抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Machine Learning is the study of methods for programming computers to learn. Computers are applied to a wide range of tasks, and for most of these it is relatively easy for programmers to design and implement the necessary software. However, there are many tasks for which this is difficult or impossible. These can be divided into four general categories. First, there are problems for which there exist no human experts. For example, in modern automated manufacturing facilities, there is a need to predict machine failures before they occur by analyzing sensor readings. Because the machines are new, there are no human experts who can be interviewed by a programmer to provide the knowledge necessary to build a computer system. A machine learning system can study recorded data and subsequent machine failures and learn prediction rules. Second, there are problems where human experts exist, but where they are unable to explain their expertise. This is the case in many perceptual tasks, such as speech recognition, hand-writing recognition, and natural language understanding. Virtually all humans exhibit expert-level abilities on these tasks, but none of them can describe the detailed steps that they follow as they perform them. Fortunately, humans can provide machines with examples of the inputs and correct outputs for these tasks, so machine learning algorithms can learn to map the inputs to the outputs. Third, there are problems where phenomena are changing rapidly. In finance, for example, people would like to predict the future behavior of the stock market, of consumer purchases, or of exchange rates. These behaviors change frequently, so that even if a programmer could construct a good predictive computer program, it would need to be rewritten frequently. A learning program can relieve the programmer of this burden by constantly modifying and tuning a set of learned prediction rules. Fourth, there are applications that need to be customized for each computer user separately. Consider, for example, a program to filter unwanted electronic mail messages. Different users will need different filters. It is unreasonable to expect each user to program his or her own rules, and it is infeasible to provide every user with a software engineer to keep the rules up-to-date. A machine learning system can learn which mail messages the user rejects and maintain the filtering rules automatically. Machine learning addresses many of the same research questions as the fields of statistics, data mining, and psychology, but with differences of emphasis. Statistics focuses on understanding the phenomena that have generated the data, often with the goal of testing different hypotheses about those phenomena. Data mining seeks to find patterns in the data that are understandable by people. Psychological studies of human learning aspire to understand the mechanisms underlying the various learning behaviors exhibited by people (concept learning, skill acquisition, strategy change, etc.).

Machine learning

Today's Web-enabled deluge of electronic data calls for automated methods of data analysis. Machine learning provides these, developing methods that can automatically detect patterns in data and then use the uncovered patterns to predict future data. This textbook offers a comprehensive and self-contained introduction to the field of machine learning, based on a unified, probabilistic approach. The coverage combines breadth and depth, offering necessary background material on such topics as probability, optimization, and linear algebra as well as discussion of recent developments in the field, including conditional random fields, L1 regularization, and deep learning. The book is written in an informal, accessible style, complete with pseudo-code for the most important algorithms. All topics are copiously illustrated with color images and worked examples drawn from such application domains as biology, text processing, computer vision, and robotics. Rather than providing a cookbook of different heuristic methods, the book stresses a principled model-based approach, often using the language of graphical models to specify models in a concise and intuitive way. Almost all the models described have been implemented in a MATLAB software package--PMTK (probabilistic modeling toolkit)--that is freely available online. The book is suitable for upper-level undergraduates with an introductory-level college math background and beginning graduate students.

Machine Learning : A Probabilistic Perspective

Part I. Experimental Studies: 2. Experiment in psychology 3. Experiments on perceiving III Experiments on imaging 4-8. Experiments on remembering: (a) The method of description (b) The method of repeated reproduction (c) The method of picture writing (d) The method of serial reproduction (e) The method of serial reproduction picture material 9. Perceiving, recognizing, remembering 10. A theory of remembering 11. Images and their functions 12. Meaning Part II. Remembering as a Study in Social Psychology: 13. Social psychology 14. Social psychology and the matter of recall 15. Social psychology and the manner of recall 16. Conventionalism 17. The notion of a collective unconscious 18. The basis of social recall 19. A summary and some conclusions.

Remembering. A Study in Experimental and Social Psychology, Cambridge (University Press) 1964.

We consider the problem of embedding entities and relationships of multi-relational data in low-dimensional vector spaces. Our objective is to propose a canonical model which is easy to train, contains a reduced number of parameters and can scale up to very large databases. Hence, we propose TransE, a method which models relationships by interpreting them as translations operating on the low-dimensional embeddings of the entities. Despite its simplicity, this assumption proves to be powerful since extensive experiments show that TransE significantly outperforms state-of-the-art methods in link prediction on two knowledge bases. Besides, it can be successfully trained on a large scale data set with 1M entities, 25k relationships and more than 17M training samples.

/pdf/translating-embeddings-for-modeling-multi-relational-data-k0qom0snwv.pdf

Translating Embeddings for Modeling Multi-relational Data

In coming to understand the world-in learning concepts, acquiring language, and grasping causal relations-our minds make inferences that appear to go far beyond the data available. How do we do it? This review describes recent approaches to reverse-engineering human learning and cognitive development and, in parallel, engineering more humanlike machine learning systems. Computational models that perform probabilistic inference over hierarchies of flexibly structured representations can address some of the deepest questions about the nature and origins of human thought: How does abstract knowledge guide learning and reasoning from sparse data? What forms does our knowledge take, across different domains and tasks? And how is that abstract knowledge itself acquired?

/pdf/how-to-grow-a-mind-statistics-structure-and-abstraction-21o338o2i1.pdf

How to Grow a Mind: Statistics, Structure, and Abstraction

https://cseweb.ucsd.edu/%7Egary/PAPER-SUGGESTIONS/tenenbaum-et-al-tics-2006.pdf

Theory-based Bayesian models of inductive learning and reasoning

Relationships between concepts account for a large proportion of semantic knowledge. We present a nonparametric Bayesian model that discovers systems of related concepts. Given data involving several sets of entities, our model discovers the kinds of entities in each set and the relations between kinds that are possible or likely. We apply our approach to four problems: clustering objects and features, learning ontologies, discovering kinship systems, and discovering structure in political data.

/pdf/learning-systems-of-concepts-with-an-infinite-relational-4rg99vom9w.pdf

Learning systems of concepts with an infinite relational model

Algorithms for finding structure in data have become increasingly important both as tools for scientific data analysis and as models of human learning, yet they suffer from a critical limitation Scientists discover qualitatively new forms of structure in observed data: For instance, Linnaeus recognized the hierarchical organization of biological species, and Mendeleev recognized the periodic structure of the chemical elements Analogous insights play a pivotal role in cognitive development: Children discover that object category labels can be organized into hierarchies, friendship networks are organized into cliques, and comparative relations (eg, "bigger than" or "better than") respect a transitive order Standard algorithms, however, can only learn structures of a single form that must be specified in advance: For instance, algorithms for hierarchical clustering create tree structures, whereas algorithms for dimensionality-reduction create low-dimensional spaces Here, we present a computational model that learns structures of many different forms and that discovers which form is best for a given dataset The model makes probabilistic inferences over a space of graph grammars representing trees, linear orders, multidimensional spaces, rings, dominance hierarchies, cliques, and other forms and successfully discovers the underlying structure of a variety of physical, biological, and social domains Our approach brings structure learning methods closer to human abilities and may lead to a deeper computational understanding of cognitive development

/pdf/the-discovery-of-structural-form-2s0i2kda01.pdf

The discovery of structural form

For over 200 years, philosophers and mathematicians have be en using probability theory to describe human cognition. While the theory of prob abilities was first developed as a means of analyzing games of chance, it quickly took on a larger and deeper significance as a formal account of how rational agents should reason in situations of uncertainty (Gigerenzer et al., 1989; Hacking, 1975). Our goal in this ch apter is to illustrate the kinds of computational models of cognition that we can build if we assume that human learning and inference approximately follow the principles of Bayesian probabilistic inference, and to explain some of the mathematical ideas and techniques underlying those models

/pdf/bayesian-models-of-cognition-5uzrkid8lo.pdf

Charles Kemp

Papers

How to Grow a Mind: Statistics, Structure, and Abstraction

Theory-based Bayesian models of inductive learning and reasoning

Learning systems of concepts with an infinite relational model

The discovery of structural form

Bayesian models of cognition