Charles Kilo

TL;DR: Several lines of evidence support the likelihood that the increased cytosolic ratio of free NADH/NAD+ caused by hyperglycemia, referred to as pseudohypoxia, is a characteristic feature of poorly controlled diabetes that mimics the effects of true hypoxia on vascular and neural function and plays an important role in the pathogenesis of diabetic complications.

TL;DR: A fourth type of humoral activity, that of hyperglucagonism, associated with an alpha-cell carcinoma of the pancreatic islets is reported, probable that cases of this disorder are at present unrecognized, or classified otherwise.

TL;DR: Observations on diabetics suggest that basement membrane width is probably normal in most subjects prior to the onset of carbohydrate intolerance and demonstrate that both the magnitude and incidence of basement membrane thickening increase with longer known duration of carbohydrates intolerance.

TL;DR: Observations indicate that early diabetes-induced hemodynamic changes and increased vascular albumin permeation and urinary albumin excretion are aldose reductase-linked phenomena, and increases in blood flow may reflect impaired contractile function of smooth muscle cells in resistance arterioles.

TL;DR: Combining aliskiren with ramipril provided a greater reduction in msDBP than either drug alone in patients with diabetes and hypertension, despite large increases in PRC in all treatment groups.