C
Charles Pilette
Researcher at Cliniques Universitaires Saint-Luc
Publications - 165
Citations - 5004
Charles Pilette is an academic researcher from Cliniques Universitaires Saint-Luc. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 33, co-authored 130 publications receiving 3890 citations. Previous affiliations of Charles Pilette include Catholic University of Leuven & National Institutes of Health.
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Journal ArticleDOI
Sublingual grass pollen immunotherapy is associated with increases in sublingual Foxp3‐expressing cells and elevated allergen‐specific immunoglobulin G4, immunoglobulin A and serum inhibitory activity for immunoglobulin E‐facilitated allergen binding to B cells
Guy W. Scadding,Mohamed H. Shamji,Mikila R. Jacobson,D. Lee,Duncan R. Wilson,Marcia Torres Lima,L. Pitkin,Charles Pilette,Kayhan T. Nouri-Aria,Stephen R. Durham +9 more
TL;DR: This research attacked the mechanisms of sublingual immunotherapy using a simple, straightforward, and scalable approach called “shots in the arm” instead of a more complicated “ pellets in the stomach” approach.
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Grass Pollen Immunotherapy Induces an Allergen-Specific IgA2 Antibody Response Associated with Mucosal TGF-β Expression
Charles Pilette,Kayhan T. Nouri-Aria,Mikila R. Jacobson,Louisa K. Wilcock,Bruno Detry,Samantha Walker,J.N. Francis,Stephen R. Durham +7 more
TL;DR: This study shows for the first time that the IgA response to IT is selective for IgA2, correlates with increased local TGF-β expression, and induces monocyte IL-10 expression, suggesting that IgA Abs could thereby contribute to the tolerance developed in IT-treated allergic patients.
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Heterogeneity of phenotypes in severe asthmatics: The Belgian Severe Asthma Registry (BSAR)
Florence Schleich,Guy Brusselle,Renaud Louis,Olivier Vandenplas,Alain Michils,Charles Pilette,Rudi Peché,Maïté Manise,Guy Joos +8 more
TL;DR: In this cohort of patients with severe asthma, the majority displayed indices of persistent airflow limitation and eosinophilic inflammation despite high-dose corticosteroids, suggesting potential for eOSinophil-targeted biotherapies.
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Asthma phenotypes and IgE responses.
Antoine Froidure,Antoine Froidure,Jonathan Mouthuy,Jonathan Mouthuy,Stephen R. Durham,Pascal Chanez,Yves Sibille,Charles Pilette,Charles Pilette +8 more
TL;DR: The discovery of IgE represented a major breakthrough in allergy and asthma research, whereas the clinical interest given to IgE in asthma has been blurred until the arrival of anti-IgE biotherapy, which has not yet clearly positioned IgE among biomarkers of asthma.
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''Real-life'' effectiveness of omalizumab in patients with severe persistent allergic asthma: The PERSIST study *
Guy Brusselle,Alain Michils,Renaud Louis,Lieven Dupont,B. Van de Maele,A. Delobbe,Charles Pilette,Christopher S. Lee,Christopher S. Lee,Sandra Gurdain,Stefaan Vancayzeele,P. Lecomte,Christine Hermans,Karen MacDonald,MinKyoung Song,Ivo Abraham +15 more
TL;DR: Under real-life conditions, omalizumab is effective as add-on therapy in the treatment of patients with persistent severe allergic asthma, and better physician-rated effectiveness, greater improvements in quality of life, greater reductions in exacerbation rates, and greater reduction in healthcare utilization are reported.