C
Charles Ramassamy
Researcher at Institut national de la recherche scientifique
Publications - 99
Citations - 5460
Charles Ramassamy is an academic researcher from Institut national de la recherche scientifique. The author has contributed to research in topics: Oxidative stress & Neuroprotection. The author has an hindex of 35, co-authored 91 publications receiving 4825 citations. Previous affiliations of Charles Ramassamy include Université du Québec & Laval University.
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Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: A review of their intracellular targets
TL;DR: Increasing number of studies demonstrated the efficacy of polyphenolic antioxidants from fruits and vegetables to reduce or to block neuronal death occurring in the pathophysiology of these disorders, and revealed that other mechanisms than the antioxidant activities could be involved in the neuroprotective effect of these phenolic compounds.
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Challenges for research on polyphenols from foods in Alzheimer's disease: bioavailability, metabolism, and cellular and molecular mechanisms.
TL;DR: The focus of this review is aimed at presenting the role of some polyphenols from fruits, vegetables, and beverages in neuroprotection and particularly in Alzheimer's disease and the research challenges in this area.
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The Ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by beta-amyloid.
Stéphane Bastianetto,Charles Ramassamy,Sylvain Doré,Yves Christen,Judes Poirier,Rémi Quirion +5 more
TL;DR: The results suggest that the neuroprotective effects of EGb 761 are partly associated with its antioxidant properties and highlight its possible effectiveness in neurodegenerative diseases, e.g. AD via the inhibition of Aβ‐induced toxicity and cell death.
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Dehydroepiandrosterone (DHEA) protects hippocampal cells from oxidative stress-induced damage.
TL;DR: The antioxidant effects of DHEA are investigated in models of oxidative stress using rat primary hippocampal cells and human hippocampal tissue from AD patients and age-matched controls to suggest that D HEA may be useful in treating age-related central nervous system diseases based on its protective effects in the hippocampus.
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Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer’s disease is related to the apolipoprotein E genotype
Charles Ramassamy,Diana A. Averill,Uwe Beffert,Stéphane Bastianetto,Louise Théroux,Suzanne Lussier-Cacan,Jeffrey S. Cohn,Yves Christen,Jean Davignon,Rémi Quirion,Judes Poirier +10 more
TL;DR: It is demonstrated that oxidative stress-induced injury and protection by antioxidants in the frontal cortex of AD cases are related to the APOE genotype.