Charles W. Bourque

TL;DR: The highly polarized AQP4 expression indicates that these cells are equipped with specific membrane domains that are specialized for water transport, thereby mediating the flow of water between glial cells and the cavities filled with CSF and the intravascular space.

TL;DR: Recent advances in the understanding of the molecular, cellular and network mechanisms that mediate the central control of osmotic homeostasis in mammals are reviewed.

TL;DR: Intracacellular recordings in hypothalamic explants have shown that changes in electrical activity are associated with proportional changes in the frequency of glutamatergic excitatory postsynaptic potentials derived from osmosensitive OVLT neurons, suggesting that these mechanisms may participate in the osmotic regulation of neurohypophysial hormone release in situ.

TL;DR: It is reported that changes in cell volume accompany physiological variations in fluid osmolality and that these modulate the activity of mechanosensitive cation channels in a way that is consistent with the macroscopic regulation of membrane voltage and action potential discharge.

TL;DR: Results suggest that the Trpv1 gene may encode a central component of the osmoreceptor, and are suggested to suggest that body fluid homeostasis requires the release of arginine-vasopressin from the neurohypophysis through specific and highly sensitive 'osmoreceptors' in the hypothalamus.