M
Mahmood Amiry-Moghaddam
Researcher at University of Oslo
Publications - 82
Citations - 7627
Mahmood Amiry-Moghaddam is an academic researcher from University of Oslo. The author has contributed to research in topics: Astrocyte & Aquaporin 4. The author has an hindex of 34, co-authored 78 publications receiving 6834 citations. Previous affiliations of Mahmood Amiry-Moghaddam include Aarhus University.
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Journal ArticleDOI
Specialized membrane domains for water transport in glial cells : high-resolution immunogold cytochemistry of aquaporin-4 in rat brain
Søren Nielsen,Erlend A. Nagelhus,Mahmood Amiry-Moghaddam,Charles W. Bourque,Peter Agre,Ole Petter Ottersen +5 more
TL;DR: The highly polarized AQP4 expression indicates that these cells are equipped with specific membrane domains that are specialized for water transport, thereby mediating the flow of water between glial cells and the cavities filled with CSF and the intravascular space.
Journal ArticleDOI
The molecular basis of water transport in the brain.
TL;DR: Light is shed on the molecular basis for brain water transport and a class of specialized water channels in the brain that might be crucial to the physiological and pathophysiological handling of water are identified.
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An α-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain
Mahmood Amiry-Moghaddam,Takashi Otsuka,Patricia D. Hurn,Richard J. Traystman,Finn Mogens Haug,Stanley C. Froehner,Marvin E. Adams,John D. Neely,Peter Agre,Ole Petter Ottersen,Anish Bhardwaj +10 more
TL;DR: A specific, syntrophin-dependent AQP4 pool that is expressed at distinct membrane domains and which mediates bidirectional transport of water across the brain–blood interface is identified and may be a target for treatment of brain edema.
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Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein
John D. Neely,Mahmood Amiry-Moghaddam,Ole Petter Ottersen,Stanley C. Froehner,Peter Agre,Marvin E. Adams +5 more
TL;DR: It is demonstrated that perivascular localization of AQP4 in brain requires α-Syn, and stability of AQD4 in the membrane is increased by the C-terminal PDZ-binding motif, which is tethered to syntrophin at this site.
Journal ArticleDOI
Delayed K+ clearance associated with aquaporin-4 mislocalization: Phenotypic defects in brains of α-syntrophin-null mice
Mahmood Amiry-Moghaddam,Anne Williamson,Maria Palomba,Tore Eid,Nihal C. de Lanerolle,Erlend A. Nagelhus,Marvin E. Adams,Stanley C. Froehner,Peter Agre,Ole Petter Ottersen +9 more
TL;DR: It is proposed that water flux through perivascular AQP4 is needed to sustain efficient removal of K+ after neuronal activation.