C
Charles W. Nichols
Researcher at University of Pennsylvania
Publications - 47
Citations - 2006
Charles W. Nichols is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Retina & Retinitis. The author has an hindex of 22, co-authored 47 publications receiving 1881 citations. Previous affiliations of Charles W. Nichols include Scheie Eye Institute.
Papers
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Journal ArticleDOI
Combined autophagy and proteasome inhibition: a phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed/refractory myeloma.
Dan T. Vogl,Edward A. Stadtmauer,Kay See Tan,Daniel F. Heitjan,Lisa E. Davis,Laura Pontiggia,Reshma Rangwala,Reshma Rangwala,Shengfu Piao,Yunyoung C. Chang,Yunyoung C. Chang,Emma C. Scott,Thomas M. Paul,Charles W. Nichols,David L. Porter,Janeen Kaplan,Gayle Mallon,James E. Bradner,Ravi K. Amaravadi +18 more
TL;DR: Combined targeting of proteasomal and autophagic protein degradation using bortezomib and hydroxychloroquine is feasible and a potentially useful strategy for improving outcomes in myeloma therapy.
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Paralysis of the awake human: visual perceptions.
John K. Stevens,Robert C. Emerson,George L. Gerstein,Tamas Kallos,Gordon R. Neufeld,Charles W. Nichols,Alan C. Rosenquist +6 more
TL;DR: Displacement in the direction of the intended eye movement without jumping and a sensation that greateffort was required to move the eye were reported.
Journal ArticleDOI
Retinal Vascular Autoregulation in Diabetes Mellitus
Stephen H. Sinclair,Juan E. Grunwald,Charles E. Riva,Seth Braunstein,Charles W. Nichols,Stanley Schwartz +5 more
TL;DR: The blue field entoptic technique was used to study autoregulation of the macular retinal circulation in response to acute alterations of intraocular pressure in 71 diabetic eyes and 30 normals matched for age, systemic blood pressure, and ophthalmic artery diastolic pressure to find an abnormal IOPmax and no hyperemic response.
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Comparison of the localization of acetylcholinesterase and non‐specific cholinesterase activities in mammalian and avian retians
TL;DR: The amacrine cells appeared to be the major or sole source of acetylcholinesterase for the inner plexiform layer of the retina, and the possible function of this enzyme with regard to synaptic transmission in the retina is discussed.
Journal ArticleDOI
A Permeability Defect of the Retinal Pigment Epithelium: Occurrence in Early Streptozocin Diabetes
TL;DR: The permeability of the blood-retina barrier was tested in rats with early streptozocin-induced diabetes and no fault whatsoever in the blood retina barrier was found.