Charlotte Helfrich-Förster

TL;DR: Results reveal PDF as an important circadian mediator whose expression and function are downstream of the clockworks, and separate elements of the central pacemaking machinery regulate pdf or its product in novel and different ways.

TL;DR: It is shown that some PER neurons are also immunostained with an antiserum against the crustacean pigment-dispersing hormone (PDH), which reveals the entire arborization pattern of these pacemaker cells.

TL;DR: CRY overexpression in brain pacemaker cells increases behavioral photosensitivity, and this restricted CRY expression also rescues all circadian defects of cry(b) behavior.

TL;DR: It is shown that Drosophila uses at least three light input pathways for this entrainment: cryptochrome, acting in the pacemaker cells themselves, the compound eyes, and extraocular photoreception, possibly involving an internal structure known as the Hofbauer-Buchner eyelet, which is located underneath the compound eye and projects to thepacemaker center in the brain.

TL;DR: It is shown that ventral lateral neurons (LNvs) are occasionally present and provoke robust circadian rhythmicity in disco mutants and it is suggested that the presence of single LNvs is sufficient to provoke robust rhythms in locomotor activity if the LNv terminals reach the superior protocerebrum.