Charlotte Seng

TL;DR: In this article, a temporally-resolved surfaceome analysis of primary neuron cultures was performed to reveal dynamic surface protein clusters that reflect the functional requirements during distinct stages of neuronal development.

TL;DR: An amendment to this paper has been published and can be accessed via a link at the top of the paper.

TL;DR: This article investigated hippocampal mossy fiber sprouting to gain insight into wiring mechanisms in mature circuits and found that sole ectopic expression of Id2 in granule cells is capable of driving mossy fibre sprouting in healthy adult mouse and rat.

TL;DR: Evidence is brought together from different areas of neuroscience—such as neurological disorders, adult‐brain neurogenesis, innate behaviours, cell grafting, and in vivo cell reprogramming—which demonstrates robust circuit formation in adult brain, highlighting that the adult brain has higher capacity for structural plasticity than previously recognized.

TL;DR: This work investigated the epilepsy-associated mossy fiber sprouting in the adult hippocampus and asked which cell surface molecules define its target specificity and used CRISPR/Cas9 genome editing to disrupt the Pcdh11x gene and characterized its consequences on sprouting.