C
Chen Ling
Researcher at Fudan University
Publications - 66
Citations - 2130
Chen Ling is an academic researcher from Fudan University. The author has contributed to research in topics: Transduction (genetics) & Adeno-associated virus. The author has an hindex of 25, co-authored 62 publications receiving 1755 citations. Previous affiliations of Chen Ling include University of Florida.
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Three advantages of using traditional Chinese medicine to prevent and treat tumor.
TL;DR: In this article, the authors summarize the advantages of TCM from three aspects: preventing tumorigenesis, attenuating toxicity and enhancing the treatment effect; and reducing tumor recurrence and metastasis.
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High-efficiency transduction and correction of murine hemophilia B using AAV2 vectors devoid of multiple surface-exposed tyrosines.
David M. Markusic,Roland W. Herzog,George Aslanidi,Brad E. Hoffman,Baozheng Li,Mengxin Li,Giridhara R. Jayandharan,Giridhara R. Jayandharan,Chen Ling,Irene Zolotukhin,Wenqin Ma,Sergei Zolotukhin,Arun Srivastava,Li Zhong +13 more
TL;DR: In summary, introduction of multiple tyrosine-mutations into the AAV2 capsid results in vectors that yield at least 30-fold improvement of transgene expression, thereby lowering the required therapeutic dose and potentially vector-related immunogenicity.
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Optimization of the capsid of recombinant adeno-associated virus 2 (AAV2) vectors: the final threshold?
George Aslanidi,Angela Rivers,Luis Ortiz,Liujiang Song,Liujiang Song,Chen Ling,Lakshmanan Govindasamy,Kim Van Vliet,Mengqun Tan,Mavis Agbandje-McKenna,Arun Srivastava +10 more
TL;DR: The generation of a novel Y444+500+730F+T491V quadruple-mutant AAV2 vector with potential for use in liver-directed human gene therapy and observations suggest that further optimization of the A AV2 capsid by targeting amino acid residues involved in phosphorylation may not be possible.
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Lignin Nanotubes As Vehicles for Gene Delivery into Human Cells
TL;DR: Cytotoxicity studies with human HeLa cells showed that concentrations of up to 90 mg/mL are tolerated, which is a 10-fold higher concentration than observed for single- or multiwalled carbon nanotubes (CNTs).
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mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system
TL;DR: A complex neuron-intrinsic balancing mechanism involving AKT as the nodal point of PI3K, mTORC1/2 and GSK3β that coordinates both positive and negative cues to regulate adult CNS axon regeneration is revealed.