A
Arun Srivastava
Researcher at University of Florida
Publications - 230
Citations - 13059
Arun Srivastava is an academic researcher from University of Florida. The author has contributed to research in topics: Transduction (genetics) & Adeno-associated virus. The author has an hindex of 59, co-authored 222 publications receiving 12155 citations. Previous affiliations of Arun Srivastava include Indiana University – Purdue University Indianapolis & Christian Medical College & Hospital.
Papers
More filters
Journal ArticleDOI
Nucleotide sequence and organization of the adeno-associated virus 2 genome.
TL;DR: The complete nucleotide sequence of the adeno-associated virus 2 genome was determined and genome segments were assigned that code for three major viral capsid proteins and, possibly, some as-yet-unidentified, nonstructural viral proteins.
PatentDOI
Human fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2
TL;DR: In this paper, it was shown that AAV requires human fibroblast growth factor receptor 1 (FGFR1) as a co-receptor for successful viral entry into the host cell.
Journal ArticleDOI
Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses.
Li Zhong,Baozheng Li,Cathryn Mah,Lakshmanan Govindasamy,Mavis Agbandje-McKenna,Mario Cooper,Roland W. Herzog,Irene Zolotukhin,Kenneth H. Warrington,Kirsten A. Weigel-Van Aken,Jacqueline A. Hobbs,Sergei Zolotukhin,Nicholas Muzyczka,Arun Srivastava +13 more
TL;DR: It is documented that site-directed mutagenesis of surface-exposed tyrosine residues leads to production of vectors that transduce HeLa cells and murine hepatocytes nearly 30-fold more efficiently in vivo at a log lower vector dose.
Journal ArticleDOI
Impact, Diagnosis and Treatment of von Willebrand Disease*
J E Sadler,P. M. Mannucci,Erik Berntorp,Nikolay P. Bochkov,Victor Boulyjenkov,David Ginsburg,Dominique Meyer,Ian R. Peake,Francesco Rodeghiero,Arun Srivastava +9 more
TL;DR: There are at least 580,000 persons with symptomatic VWD worldwide who could benefit from appropriate diagnosis followed by replacement or pharmacological therapy, and 80% of these persons live in the developing world.
Journal ArticleDOI
High-efficiency Transduction of the Mouse Retina by Tyrosine-mutant AAV Serotype Vectors
Hilda Petrs-Silva,Astra Dinculescu,Qiuhong Li,Seok-Hong Min,Vince A. Chiodo,Jijing Pang,Li Zhong,Sergei Zolotukhin,Arun Srivastava,Alfred S. Lewin,William W. Hauswirth +10 more
TL;DR: Efficient transduction of the ganglion cell layer by AAV serotype 8 or 9 mutant vectors is shown, thus providing additional tools besides AAV2 for targeting these cells, which have a great potential for future therapeutic applications for retinal degenerations and ocular neovascular diseases.