Chen-Liu Ye

TL;DR: The proposed sensor, which has simplicity in operation and ease of miniaturization, detected the target of interest in total nucleic acid extracts derived from clinical serum samples with excellent results, thereby demonstrating its considerable diagnostic potential in fields ranging from virus detection to the diagnosis of genetic diseases.

TL;DR: The proposed eLCR, due to its advantages in simple primer design, operational ease and ease of miniaturization, has demonstrated its considerable potential for point-of-care testing in the diagnosis of point mutation-related diseases and personalized medicine.

TL;DR: A new chimeric DNA probe-aided ligase chain reaction-based electrochemical method developed for RNA mutation detection through the BSA-based carrier platform and the horseradish peroxidase-hydrogen peroxide-tetramethylbenzidine (HRP-H2O2-TMB) system shows excellent performance in discriminating single base-mismatched sequences.

TL;DR: This method combined terminal deoxynucleoside transferase (TdTase)–mediated isothermal amplification and polyHRP catalysis to achieve dual-signal enhancement, and was featured with low-density DNA monolayer for its employment of only 2 nM capture probes.

TL;DR: In this article, a novel electrochemical cytosensor was developed for detection of human osteosarcoma 143B cells based on graphene-three dimensional nanostructure gold nanocomposites (G-3D Au) using facile and rapid one-step electrochemical co-reduction technique.