C
Cheng-Hao Chien
Researcher at Academia Sinica
Publications - 13
Citations - 446
Cheng-Hao Chien is an academic researcher from Academia Sinica. The author has contributed to research in topics: Lipid droplet & Energy source. The author has an hindex of 9, co-authored 13 publications receiving 340 citations. Previous affiliations of Cheng-Hao Chien include National Taiwan University & Tufts University.
Papers
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Journal ArticleDOI
Genetic identification of leptin neural circuits in energy and glucose homeostases.
TL;DR: A systematic, unbiased survey of leptin-responsive neurons in streptozotocin-induced diabetic mice and exploit CRISPR–Cas9-mediated genetic ablation of LEPR in AGRP neurons causes severe obesity and diabetes, faithfully replicating the phenotype of Leprdb/db mice are found.
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In-cell optical imaging of exogenous G-quadruplex DNA by fluorogenic ligands
TL;DR: A G-quadruplex (G4) ligand is introduced, 3,6-bis(1-methyl-4-vinylpyridinium) carbazole diiodide, to monitor the cellular uptake of naked GROs and map their intracellular localizations in living cells by using confocal microscopy.
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Fluorescent probe for visualizing guanine-quadruplex DNA by fluorescence lifetime imaging microscopy
Ting-Yuan Tseng,Cheng-Hao Chien,Cheng-Hao Chien,Jen-Fei Chu,Wei-Chun Huang,Wei-Chun Huang,Mei-Ying Lin,Cheng-Chung Chang,Ta-Chau Chang,Ta-Chau Chang +9 more
TL;DR: By using fluorescence lifetime imaging microscopy, this work demonstrated an innovative methodology for visualizing the localization of G4 structures as well as mapping the localized of different G4 structure in living cells.
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Aggregation induced photodynamic therapy enhancement based on linear and nonlinear excited FRET of fluorescent organic nanoparticles.
Meng-Chieh Hsieh,Cheng-Hao Chien,Cheng-Hao Chien,Cheng-Chung Chang,Ta-Chau Chang,Ta-Chau Chang +5 more
TL;DR: A binary molecule can self-assemble to form fluorescent organic nanoparticles (FONs) based on the Aggregation-Induced Emission Enhancement (AIEE) property and subsequently, presents an efficient fluorescence resonance energy transfer (FRET) to generate singlet oxygen under linear and nonlinear light sources.
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Label-free imaging of Drosophila in vivo by coherent anti-Stokes Raman scattering and two-photon excitation autofluorescence microscopy
TL;DR: A combination of coherent anti-Stokes Raman scattering (CARS) and two-photon excitation autofluorescence (TPE-F) microscopy is introduced to achieve label-free imaging of Drosophila in vivo at larval and pupal stages.