Cheng Liu

TL;DR: It is demonstrated for the first time that legumain, a member of the asparaginyl endopeptidase family functioning as a stress protein, overexpressed by TAMs, provides an ideal target molecule to suppress tumor growth and metastasis.

TL;DR: A novel murine gene, hepcarcin (hcn), encoding a 7-kb mRNA-like transcript is identified, the murine ortholog of the human alpha gene, that is, MALAT-1, consistent with a highly conserved large noncoding RNA (ncRNA).

TL;DR: A prodrug strategy incorporating a legumain-cleavable peptide substrate onto doxorubicin was developed and the prototype compound exhibited reduced toxicity and was effectively tumoricidal in vivo in a murine colon carcinoma model.

TL;DR: It is shown that legumain, the only asparaginyl endopeptidase of the mammalian genome, is highly expressed by neoplastic, stromal, and endothelial cells in solid tumors and thus provides new potentials for the rational development of more effective functionally targeted cancer therapeutics.

TL;DR: It is found that the channel structures delineated by PSMA-expressing cells in human and rat prostate tumors are in functional continuity with the vasculature and thus form part of tumor microvasculature, which expands the therapeutic potential for selective infarctive ablation of tumors.