C
Cheng Wei Lu
Researcher at Yuan Ze University
Publications - 29
Citations - 635
Cheng Wei Lu is an academic researcher from Yuan Ze University. The author has contributed to research in topics: Glutamate receptor & Channel blocker. The author has an hindex of 15, co-authored 29 publications receiving 518 citations. Previous affiliations of Cheng Wei Lu include Chang Gung University of Science and Technology & Memorial Hospital of South Bend.
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Curcumin inhibits glutamate release in nerve terminals from rat prefrontal cortex: possible relevance to its antidepressant mechanism.
TL;DR: Curcumin inhibits evoked glutamate release from rat prefrontocortical synaptosomes by the suppression of presynaptic Ca(v)2.1 channels, which suggests that curcumin and fluoxetine use a common intracellular mechanism to inhibit glutamateRelease from rat prefrontal cortex nerve terminals.
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Osthole and imperatorin, the active constituents of Cnidium monnieri (L.) Cusson, facilitate glutamate release from rat hippocampal nerve terminals
TL;DR: The results suggest that osthole or imperatorin effects a facilitation of glutamate release from nerve terminals by positively modulating N- and P/Q-type Ca(2+) channel activation through a signaling cascade involving PKC.
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Luteolin protects the hippocampus against neuron impairments induced by kainic acid in rats.
TL;DR: Luteolin protected rat brains from KA-induced excitotoxic damage by reducing glutamate levels, mitigating inflammation, and enhancing Akt activation in the hippocampus, suggesting that luteolin may be beneficial for preventing or treating brain disorders associated with excited neuronal damage.
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Acacetin inhibits glutamate release and prevents kainic acid-induced neurotoxicity in rats
TL;DR: It is demonstrated that the natural compound, acacetin, inhibits glutamate release from hippocampal synaptosomes by attenuating voltage-dependent Ca2+ entry and effectively prevents KA-induced in vivo excitotoxicity.
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Hesperidin inhibits glutamate release and exerts neuroprotection against excitotoxicity induced by kainic acid in the hippocampus of rats
Chia Ying Chang,Tzu Yu Lin,Cheng Wei Lu,Shu Kuei Huang,Ying Chou Wang,Shang Shing Peter Chou,Su-Jane Wang +6 more
TL;DR: It is demonstrated that hesperidin inhibits evoked glutamate release in vitro and attenuates in vivo KA-induced neuronal death in the hippocampus, indicating that hes peridin may be a promising candidate for preventing or treating glutamate excitotoxicity related brain disorders such as neurodegenerative diseases.