C
Cheng-Xin Gong
Researcher at University of York
Publications - 171
Citations - 17359
Cheng-Xin Gong is an academic researcher from University of York. The author has contributed to research in topics: Hyperphosphorylation & Tau protein. The author has an hindex of 67, co-authored 160 publications receiving 15144 citations. Previous affiliations of Cheng-Xin Gong include Nantong University.
Papers
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Journal ArticleDOI
Tau pathology in Alzheimer disease and other tauopathies
Khalid Iqbal,Alejandra del C. Alonso,She Chen,M. Omar Chohan,Ezzat El-Akkad,Cheng-Xin Gong,Sabiha Khatoon,Bin Li,Fei Liu,Abdur Rahman,Hitoshi Tanimukai,Inge Grundke-Iqbal +11 more
TL;DR: Inhibition of this tau abnormality is one of the most promising therapeutic approaches to AD and other tauopathies.
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Tau in Alzheimer disease and related tauopathies.
TL;DR: Inhibition of abnormal hyperphosphorylation of tau offers a promising therapeutic target for AD and related tauopathies.
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Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation
TL;DR: PP2A is the major tau phosphatase that regulates its phosphorylation at multiple sites in human brain, partially due to a downregulation of PP2A activity in AD brain.
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O-GlcNAcylation regulates phosphorylation of tau: A mechanism involved in Alzheimer's disease
TL;DR: It is demonstrated that human brain tau was modified by O-GlcNAcylation, a type of protein O-glycosylation by which the monosaccharide beta-N-acetylglucosamine (Glc NAc) attaches to serine/threonine residues via an O-linked glycosidic bond, which reveals a mechanism of regulation of tau phosphorylation.
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Mechanisms of tau-induced neurodegeneration
TL;DR: Disruption of microtubules by the non-fibrillized abnormally hyperphosphorylated tau as well as its aggregation as neurofibrillary tangles probably impair axoplasmic flow and lead to slow progressive retrograde degeneration and loss of connectivity of the affected neurons.