Showing papers by "Cheol-Su Kim published in 2007"
TL;DR: High field MR microscopy is applied to the X. laevis system and image series of dividing cells and nuclei and of the whole embryonic development from the zygote onto the hatching of the tadpole are presented.
23 citations
TL;DR: It is suggested that carbenoxolone, oleanolic acid and ursolic acid can regulate ‘mucin secretion induced by ATP’ – a phenomenon simulating mucus overproduction from inflamed airway epithelial cells – by directly acting on airway mucin‐secreting cells.
Abstract: This study investigated whether carbenoxolone, oleanolic acid and ursolic acid affect ATP-induced mucin secretion from cultured airway epithelial cells. Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled using 3H-glucosamine for 24 h and chased for 30 min in the presence of varying concentrations of each agent to assess the effects on 3H-mucin secretion. The possible cytotoxicity of each agent was investigated with a lactate dehydrogenase assay. The results were as follows: (1) carbenoxolone, oleanolic acid and ursolic acid significantly inhibited the secretion of airway mucin induced by ATP; (2) none of the compounds showed significant cytotoxicity at any concentration. This result suggests that carbenoxolone, oleanolic acid and ursolic acid can regulate ‘mucin secretion induced by ATP’ – a phenomenon simulating mucus overproduction from inflamed airway epithelial cells – by directly acting on airway mucin-secreting cells. Copyright © 2007 John Wiley & Sons, Ltd.
22 citations