C
Cherin Sohn-Lee
Researcher at Rockefeller University
Publications - 4
Citations - 1211
Cherin Sohn-Lee is an academic researcher from Rockefeller University. The author has contributed to research in topics: Locked nucleic acid & microRNA. The author has an hindex of 4, co-authored 4 publications receiving 1132 citations. Previous affiliations of Cherin Sohn-Lee include Howard Hughes Medical Institute.
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Journal ArticleDOI
The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo
Jason T. Huse,Cameron Brennan,Dolores Hambardzumyan,Boyoung Wee,John Pena,Sara H. Rouhanifard,Cherin Sohn-Lee,Carlos le Sage,Reuven Agami,Thomas Tuschl,Eric C. Holland +10 more
TL;DR: It is demonstrated that miR-26a-mediated PTEN repression in a murine glioma model both enhances de novo tumor formation and precludes loss of heterozygosity and the PTEN locus.
Journal ArticleDOI
MicroRNA-24 Regulates Vascularity After Myocardial Infarction
Jan Fiedler,Virginija Jazbutyte,Bettina C. Kirchmaier,Bettina C. Kirchmaier,Shashi Kumar Gupta,Johan M. Lorenzen,Dorothee Hartmann,Paolo Galuppo,Susanne Kneitz,John Pena,Cherin Sohn-Lee,Xavier Loyer,Juergen Soutschek,Thomas Brand,Thomas Brand,Thomas Tuschl,Joerg Heineke,Ulrich Martin,Stefan Schulte-Merker,Georg Ertl,Stefan Engelhardt,Johann Bauersachs,Thomas Thum +22 more
TL;DR: It is shown that the small noncoding RNA microRNA-24 (miR-24) is enriched in cardiac endothelial cells and considerably upregulated after cardiac ischemia, and is suitable for therapeutic intervention in the setting of ischemic heart disease.
Journal ArticleDOI
miRNA in situ hybridization in formaldehyde and EDC-fixed tissues.
John Pena,Cherin Sohn-Lee,Sara H. Rouhanifard,Janos Ludwig,Janos Ludwig,Markus Hafner,Aleksandra Mihailovic,Cindy Lim,Daniel Holoch,Philipp Berninger,Mihaela Zavolan,Thomas Tuschl +11 more
TL;DR: It is shown that in situ hybridization using conventional formaldehyde fixation results in substantial microRNA loss from mouse tissue sections, which can be prevented by fixation with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide that irreversibly immobilizes the microRNA at its 5′ phosphate.
Heart Failure MicroRNA-24 Regulates Vascularity After Myocardial Infarction
Jan Fiedler,Virginija Jazbutyte,Bettina C. Kirchmaier,Shashi Kumar Gupta,Johan Lorenzen,Dorothee Hartmann,Paolo Galuppo,Susanne Kneitz,Cherin Sohn-Lee,Xavier Loyer,Juergen Soutschek,Thomas Brand,Thomas Tuschl,Joerg Heineke,Ulrich Martin,Stefan Schulte-Merker,Georg Ertl,Stefan Engelhardt,Johann Bauersachs,Thomas Thum +19 more
TL;DR: Jan Fiedler, PhD, Virginija Jazbutyte, PhD; Bettina C. Kirchmaier, MD, Shashi K. Gupta, MSc;Johan Lorenzen, MD; Dorothee Hartmann, MSC; Paolo Galuppo, PhD and Susanne Kneitz, PhD as discussed by the authors.