S
Stefan Engelhardt
Researcher at Technische Universität München
Publications - 165
Citations - 14645
Stefan Engelhardt is an academic researcher from Technische Universität München. The author has contributed to research in topics: Heart failure & Receptor. The author has an hindex of 52, co-authored 142 publications receiving 12609 citations. Previous affiliations of Stefan Engelhardt include James Hutton Institute & Deutsche Forschungsgemeinschaft.
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Journal ArticleDOI
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
Thomas Thum,Carina Gross,Jan Fiedler,Thomas Fischer,Stephan Kissler,Markus Bussen,Paolo Galuppo,Steffen Just,Wolfgang Rottbauer,Stefan Frantz,Mirco Castoldi,Jürgen Soutschek,Victor Koteliansky,Andreas Rosenwald,M. Albert Basson,Jonathan D. Licht,John T. R. Pena,Sara H. Rouhanifard,Martina U. Muckenthaler,Thomas Tuschl,Gail R. Martin,Johann Bauersachs,Stefan Engelhardt,Stefan Engelhardt +23 more
TL;DR: It is shown that microRNA-21 regulates the ERK–MAP kinase signalling pathway in cardiac fibroblasts, which has impacts on global cardiac structure and function and confirms miR-21 as a disease target in heart failure and establishes the therapeutic efficacy of microRNA therapeutic intervention in a cardiovascular disease setting.
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MicroRNAs in the Human Heart A Clue to Fetal Gene Reprogramming in Heart Failure
Thomas Thum,Paolo Galuppo,Christian Wolf,Jan Fiedler,Susanne Kneitz,Linda W. van Laake,Pieter A. Doevendans,Christine L. Mummery,Jürgen Borlak,Axel Haverich,Carina Gross,Stefan Engelhardt,Georg Ertl,Johann Bauersachs +13 more
TL;DR: Evidence is provided that cardiac microRNAs, recently discovered key regulators of gene expression, contribute to the transcriptional changes observed in heart failure as well as changes in gene expression comparable to the failing heart.
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Cardiac fibroblast–derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy
Claudia Bang,Sandor Batkai,Seema Dangwal,Shashi Kumar Gupta,Ariana Foinquinos,Angelika Holzmann,Annette Just,Janet Remke,Karina Zimmer,Andre Zeug,Evgeni Ponimaskin,Andreas Schmiedl,Xiaoke Yin,Manuel Mayr,Rashi Halder,Andre Fischer,Stefan Engelhardt,Yuanyuan Wei,Andreas Schober,Jan Fiedler,Thomas Thum +20 more
TL;DR: It is found that cardiac fibroblasts secrete star miRNA-enriched exosomes and fibroblast-derived miR-21* is identified as a paracrine signaling mediator of cardiomyocyte hypertrophy that has potential as a therapeutic target.
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Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice.
TL;DR: It is concluded that overexpression of beta1-adrenergic receptors in the heart may lead to a short-lived improvement of cardiac function, but that increasedbeta1- adrenergic receptor signalling is ultimately detrimental.
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What Is the Role of β-Adrenergic Signaling in Heart Failure?
TL;DR: Clinically, &bgr;-adrenergic antagonists represent the most important advance in heart failure therapy, but it is still debated whether they act by blocking or by resensitizing the &b gr;- adrenergic receptor system.