C
Cheryl R. Barnes
Researcher at University of North Carolina at Chapel Hill
Publications - 5
Citations - 65
Cheryl R. Barnes is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: DNA synthesis & DNA polymerase. The author has an hindex of 5, co-authored 5 publications receiving 61 citations.
Papers
More filters
Journal ArticleDOI
Cytotoxicity of substituted alkyl-3,4-bis(4-methoxyphenyl)pyrrole-2-carboxylates in L1210 lymphoid leukemia cells.
Bruce S. Burnham,John T. Gupton,Keith Krumpe,T. Webb,Jordan S. Shuford,Brook Bowers,Amy E. Warren,Cheryl R. Barnes,Iris H. Hall +8 more
TL;DR: Two alkyl‐3,4‐bis(4‐methoxyphenyl)pyrrole‐2‐carboxylates proved to be potent cytotoxic agents in the murine L1210 lymphoid leukemia screen and caused L 1210 DNA fragmentation after 24 h incubation at 100 μM.
Journal ArticleDOI
Synthesis and cytotoxicity of 2,4-disubstituted and 2,3,4-trisubstituted brominated pyrroles in murine and human cultured tumor cells.
John T. Gupton,Bruce S. Burham,Keith Krumpe,Karen Du,James A. Sikorski,Amy E. Warren,Cheryl R. Barnes,Iris H. Hall +7 more
TL;DR: In vitro ct‐DNA Studies suggest that the agents may affect the DNA molecule itself with increased DNA viscosity and the Tmolt4 studies suggest that DNA cross‐linking of DNA strands may be present.
Journal Article
Cytotoxicity and mode of action of aliphatic dicarboxylic acids in L1210 lymphocytic leukemia cells.
TL;DR: The aliphatic dicarboxylic acid surprisingly afforded potent cytotoxicity and in vivo antineoplastic activity and was active against the growth of a variety of leukemias, lymphomas, and suspended HeLa uterine carcinoma.
Journal Article
The cytotoxicity and mode of action of 2,3,4-trisubstituted pyrroles and related derivatives in human Tmolt4 leukemia cells
John T. Gupton,B. S. Burham,Brian D. Byrd,Keith Krumpe,C. Stokes,Jordan S. Shuford,S. Winkle,T. Webb,Amy E. Warren,Cheryl R. Barnes,J. Henry,Iris H. Hall +11 more
TL;DR: Selective toxicity was demonstrated against the growth of solid tumors, e.g., human adenocarcinoma of the colon SW480 and ileum HCT-8, glioma U-87-MG, and rat UMR-106 osteosarcoma.
Journal ArticleDOI
Cytotoxicity of poly(phenolic)sulfonates and their sodium salts in l1210 lymphoid leukemia cells.
TL;DR: Poly(phenolic)-sulfonates demonstrated very good cytotoxicity against the growth of tumor cell lines (L1210, Tmolt-3, HeLa-S3) and are comparable in potency with typical clinically used anticancer drugs.