Bruce S. Burnham

TL;DR: In this article, 2,3,4-trisubstituted pyrrole systems were studied under acidic, basic and neutral conditions, and the results of such reactions have resulted in efficient and selective methodology for the synthesis of unsymmetrical 2, 3, 4 trisubstantituted Pyrrole system.

TL;DR: In this article, a novel and regiocontrolled synthesis of a known pyrrole synthetic precursor to the compounds Lukianol A and Lammelarin O dimethyl ether based on this synthetic methodology is reported.

TL;DR: In this article, a 2,4-disubstituted pyrrole from a vinamidinium salt was synthesized by acylation at the 5 position of pyrrolopyrimidine, followed by hydrolysis of the ester group at C-2 and subsequent Curtius rearrangement.

TL;DR: Many boron derivatives from different chemical classes demonstrated both cytotoxic and hypolipidemic activities, and the mode of action of these compounds appeared to be by increasing lipid excretion from the body and by inhibiting rate-limiting enzyme activities for the de novo synthesis of lipids and cholesterol.

TL;DR: Two alkyl‐3,4‐bis(4‐methoxyphenyl)pyrrole‐2‐carboxylates proved to be potent cytotoxic agents in the murine L1210 lymphoid leukemia screen and caused L 1210 DNA fragmentation after 24 h incubation at 100 μM.