Provided herein are methods and compositions for reducing or inhibiting adipogenesis of a cell, such as: correcting a mutation in Ovo like zinc finger 2 (Ovol2) gene present in the cell; increasing an amount of OVOL2 protein or a functional fragment thereof; enhancing an activity of OVOL2 protein; and/or administering a C/EBPα inhibitor that mimics OVOL2 binding to C/EBPα.

Methods and compositions for regulating adipogenesis

The present invention provides compositions and methods for identifying a subject as having a genetic predisposition to obesity or at risk of developing obesity The present invention also provides compositions and methods for expressing a CREBRF polypeptide of the invention in a cell or precursor thereof and cells expressing a nucleic acid molecule encoding a CREBRF polypeptide of the invention

Chi-Ting Su

Papers

Compositions and methods for identifying genetic predisposition to obesity and for enhancing adipogenesis