Patent
Compositions and methods for identifying genetic predisposition to obesity and for enhancing adipogenesis
Stephen T. McGarvey,Ranjan Deka,Nicola L. Hawley,Ryan Lee Minster,Zsolt Urban,Chi-Ting Su,Erin Elizabeth Kershaw,Daniel E. Weeks +7 more
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TLDR
In this article, the authors provide compositions and methods for identifying a subject as having a genetic predisposition to obesity or at risk of developing obesity and for expressing a CREBRF polypeptide of the invention in a cell or precursor thereof.Abstract:
The present invention provides compositions and methods for identifying a subject as having a genetic predisposition to obesity or at risk of developing obesity The present invention also provides compositions and methods for expressing a CREBRF polypeptide of the invention in a cell or precursor thereof and cells expressing a nucleic acid molecule encoding a CREBRF polypeptide of the inventionread more
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Patent
Methods and compositions for regulating adipogenesis
TL;DR: In this paper, methods and compositions for reducing or inhibiting adipogenesis of a cell, such as correcting a mutation in Ovo like zinc finger 2 (Ovol2) gene present in the cell, increasing an amount of OVOL2 protein or a functional fragment thereof, enhancing an activity of Ovol2 protein, and/or administering a C/EBPα inhibitor that mimics OVOL 2 binding to C/EPBPα.
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Journal ArticleDOI
A Novel Protein, Luman/CREB3 Reruitment Factor, Inhibits Luman Activation of the Unfolded Protein Response
TL;DR: The identification of a novel Luman recruitment factor (LRF), a UPR-responsive basic-region leucine zipper protein that is prone to proteasomal degradation, which is proposed to be a negative regulator of the UPR.
Journal ArticleDOI
Joint MiRNA/mRNA expression profiling reveals changes consistent with development of dysfunctional corpus luteum after weight gain
Andrew P. Bradford,Kenneth L. Jones,Katerina Kechris,Justin Chosich,Michael J. Montague,Wesley C. Warren,Margaret C. May,Zain A. Al-Safi,Satu Kuokkanen,Susan E. Appt,Alex J. Polotsky +10 more
TL;DR: The observed HFHF diet-induced changes were consistent with development of a dysfunctional CL and provide new mechanistic insights for decreased sex steroid production characteristic of obese women.
Journal ArticleDOI
Liver immune responses to inflammatory stimuli in a diet-induced obesity model of zebrafish
Gabriel Forn-Cuní,Monica Varela,Conrado M Fernández-Rodríguez,Antonio Figueras,Beatriz Novoa +4 more
TL;DR: A diet-induced obesity approach in zebrafish based on overfeeding was used to analyze liver transcriptomic modulation in the disease and to determine how obesity affects the immune response against an acute inflammatory stimulus such as lipopolysaccharide.
Patent
Methods of diagnosing and treating vascular associated maculopathy and symptoms thereof
Gregory S. Hageman,Giuliana Silvestri,Paulina Haas,Monika Fleckenstein,Christian Matthew Pappas,Guymer Robin +5 more
TL;DR: In this article, methods and compositions for the diagnosis and treatment of Vascular Associated Maculopathy, or a symptom thereof, in a subject are presented. But none of these methods are suitable for the treatment of severe maculopathy.
Patent
Materials And Methods For Inducing Apoptosis In Adipocytes
Michael B. Zemel,Xiaocun Sun +1 more
TL;DR: In this paper, the subject invention provides materials and methods of using dietary calcium, calcium-containing products, dairy and antagonists of calcitrophic hormone activity for inducing apoptosis in adipocytes in order to reduce the number of adipocytes.