C
Chia-Sheng Chang
Researcher at China Medical University (Taiwan)
Publications - 11
Citations - 1232
Chia-Sheng Chang is an academic researcher from China Medical University (Taiwan). The author has contributed to research in topics: Evans Blue & Eritoran. The author has an hindex of 8, co-authored 11 publications receiving 1164 citations.
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Journal ArticleDOI
Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial.
Steven M. Opal,Pierre-François Laterre,Bruno François,Steven P. LaRosa,Derek C. Angus,Jean-Paul Mira,Xavier Wittebole,Thierry Dugernier,Dominique Perrotin,Mark Tidswell,Luis Jauregui,Kenneth Krell,Jan Pachl,Takahashi Takeshi,Claus Peckelsen,Edward Cordasco,Chia-Sheng Chang,Sandra Oeyen,Naoki Aikawa,Tatsuya Maruyama,Roland M. H. Schein,Andre C. Kalil,Marc Van Nuffelen,Melvyn Lynn,Daniel P. Rossignol,Jagadish Gogate,Mary B. Roberts,Mary B. Roberts,Janice L. Wheeler,Jean Louis Vincent +29 more
TL;DR: Among patients with severe sepsis, the use of eritoran, compared with placebo, did not result in reduced 28-day mortality, and no significant differences were observed in any of the prespecified subgroups.
Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis
Steven M. Opal,Pierre-François Laterre,Bruno François,Steven P. LaRosa,Derek C. Angus,Jean-Paul Mira,Xavier Wittebole,Thierry Dugernier,Dominique Perrotin,Mark Tidswell,Luis Jauregui,Kenneth Krell,Jan Pachl,Takahashi Takeshi,Claus Peckelsen,Edward Cordasco,Chia-Sheng Chang,Sandra Oeyen,Naoki Aikawa,Tatsuya Maruyama,Roland M. H. Schein,Andre C. Kalil,Marc Van Nuffelen,Melvyn Lynn,Daniel P. Rossignol +24 more
TL;DR: Steven M. Opal, MDPierre-Francois Laterre, MDBruno Francois, MDSteven P. LaRosa, MDDerek C. Kalil, MD, MPHMarc Van Nuffelen, MDMelvyn Lynn, PhDDaniel P. Rossignol, PhDJogadish Gogate, PhDMary B. Roberts, MSJanice L. Wheeler, BS, RNJean-Louis Vincent, MD as discussed by the authors
Journal ArticleDOI
Intravenous mannitol does not increase blood-brain barrier permeability to inert dyes in the adult rat forebrain.
Kuen-Bao Chen,Vivi Chiali Wei,Lola Fenghuei Yen,Kin Shing Poon,Yu-Cheng Liu,Ka Shun Cheng,Chia-Sheng Chang,Ted Weita Lai +7 more
TL;DR: Direct evidence is reported that IV-M, at a dose used clinically, in contrast to the same dose of ICA- M, exerted no effect on BBB permeability to protein and small molecular tracers.
A 'membrane in syringe' technique that allows identification of the epidural space with saline while avoids injection of air into the epidural space.
Bih-Chern Lin,Kuen-Bao Chen,Chia-Sheng Chang,King-Chuen Wu,Yu-Cheng Liu,Chia-Chen Chen,Rick Sai-Chuen Wu +6 more
TL;DR: The advantage of this technique is when the syringe is filled with both normal saline and air, it can prevent injection of the air into the epidural space during identification while at the same time it does not molest the feel of compressibility.
Journal ArticleDOI
Increase in Evans blue dye extravasation into the brain in the late developmental stage.
Kuen-Bao Chen,Eva Yuhua Kuo,Kin Shing Poon,Ka Shun Cheng,Chia-Sheng Chang,Yu-Cheng Liu,Ted Weita Lai +6 more
TL;DR: A specific increase in EBD extravasation in the mature forebrain is found, and the protocol that is used may be a good template for studying developmental disruption of the BBB.