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Chia-Yu Chu
Researcher at National Taiwan University
Publications - 228
Citations - 7958
Chia-Yu Chu is an academic researcher from National Taiwan University. The author has contributed to research in topics: Medicine & Atopic dermatitis. The author has an hindex of 39, co-authored 191 publications receiving 6329 citations. Previous affiliations of Chia-Yu Chu include Charité & Taipei Medical University.
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Journal ArticleDOI
HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol
Shuen Lu Hung,Wen-Hung Chung,Wen-Hung Chung,Wen-Hung Chung,Lieh Bang Liou,Chen Chung Chu,Marie Lin,Hsien Ping Huang,Yen Ling Lin,Joung Liang Lan,Li Cheng Yang,Hong Shang Hong,Ming Jing Chen,Ping Chin Lai,Mai Szu Wu,Chia-Yu Chu,Chia-Yu Chu,Kuo Hsien Wang,Chien-Hsiun Chen,Cathy S.J. Fann,Jer-Yuarn Wu,Jer-Yuarn Wu,Yuan-Tsong Chen,Yuan-Tsong Chen +23 more
TL;DR: The results indicated that allopurinol-SCAR is strongly associated with a genetic predisposition in Han Chinese, and in particular, HLA-B*5801 allele is an important genetic risk factor for this life-threatening condition.
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Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction. Results from the prospective RegiSCAR study
Sylvia H. Kardaun,Peggy Sekula,Laurence Valeyrie-Allanore,Yvonne Liss,Chia-Yu Chu,Daniel Creamer,Alexis Sidoroff,Luigi Naldi,Maja Mockenhaupt,J.-C. Roujeau +9 more
TL;DR: Cases of severe drug hypersensitivity, demonstrating a variable spectrum of cutaneous and systemic involvement, are reported under various names, especially drug reaction with eosinophilia and systemic symptoms (DRESS).
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Tumor-Associated Macrophage-Induced Invasion and Angiogenesis of Human Basal Cell Carcinoma Cells by Cyclooxygenase-2 Induction
Jeng-Wei Tjiu,Jau-Shiuh Chen,Chia-Tung Shun,Sung-Jan Lin,Yi-Hua Liao,Chia-Yu Chu,Tsen-Fang Tsai,Hsien-Ching Chiu,Yang-Shia Dai,Hiroyasu Inoue,Pan-Chyr Yang,Min-Liang Kuo,Shiou-Hwa Jee +12 more
TL;DR: The number of TAMs infiltrating the tumor is correlated with the depth of invasion, microvessel density, and COX-2 expression in human BCC cells, and it is hypothesize that TAMs might activate COX2 in BCC cells and subsequently increase their invasion and angiogenesis.
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Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese.
Shuen-Iu Hung,Wen-Hung Chung,Zhi-Sheng Liu,Chien-Hsiun Chen,Mo-Song Hsih,Rosaline Chung-Yee Hui,Chia-Yu Chu,Yuan-Tsong Chen +7 more
TL;DR: OXC, PHT and LTG, which possess an aromatic ring just as CBZ does, when causing SJS/TEN, share a common risk allele, suggesting that aromatic antiepileptic drugs, including CBZ, OXC and PHT, should be avoided in the B*1502 carrier and caution should also be exercised for LTG.
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Drug reaction with eosinophilia and systemic symptoms: a retrospective study of 60 cases.
TL;DR: Drug reaction with eosinophilia and systemic symptoms has a variable clinical presentation, and its definition requires clarification, and early diagnosis and prompt discontinuation of offending drug regimens are essential.