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Chien-Hsiun Chen

Researcher at Academia Sinica

Publications -  55
Citations -  5152

Chien-Hsiun Chen is an academic researcher from Academia Sinica. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 17, co-authored 46 publications receiving 4198 citations. Previous affiliations of Chien-Hsiun Chen include Huafan University & China Medical University (Taiwan).

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HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol

Shuen Lu Hung, +23 more
- 15 Mar 2005 - 
TL;DR: The results indicated that allopurinol-SCAR is strongly associated with a genetic predisposition in Han Chinese, and in particular, HLA-B*5801 allele is an important genetic risk factor for this life-threatening condition.
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Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.

Anubha Mahajan, +395 more
- 01 Mar 2014 - 
TL;DR: In this paper, the authors aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry.
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A novel functional VKORC1 promoter polymorphism is associated with inter-individual and inter-ethnic differences in warfarin sensitivity

Hsiang-Yu Yuan, +11 more
- 01 Jul 2005 - 
TL;DR: The differences in allele frequencies of A/G allele and its levels of VKORC1 promoter activity may underscore the inter-individual differences in warfarin dosage as well as inter-ethnic differences between Chinese and Caucasians.
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Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Cristian Pattaro, +735 more
- 21 Jan 2016 - 
TL;DR: A meta-analysis of genome-wide association studies for estimated glomerular filtration rate suggests that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways.
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Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups

Nita A. Limdi, +19 more
- 06 May 2010 - 
TL;DR: Clinicians should recognize that, although at a population level, the contribution of VKORC1 toward dose requirements is higher in whites than in nonwhites; genotype predicts similar dose requirements across racial groups.