C
Chia-Yu Yeh
Researcher at University of North Carolina at Chapel Hill
Publications - 14
Citations - 994
Chia-Yu Yeh is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Neural stem cell & Dentate gyrus. The author has an hindex of 10, co-authored 12 publications receiving 810 citations. Previous affiliations of Chia-Yu Yeh include University of Manchester.
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Journal ArticleDOI
Astrocytes in Alzheimer’s disease
Alexei Verkhratsky,M. Olabarria,Harun N. Noristani,Chia-Yu Yeh,José J. Rodríguez,José J. Rodríguez +5 more
TL;DR: Astroglial cells are engaged in neurological diseases by determining the progression and outcome of neuropathological process, specifically involved in various neurodegenerative diseases, including Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson’s disease, and various forms of dementia.
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Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimer's disease
TL;DR: The results suggest that the AD progressive cognitive deterioration can be associated with an early reduction of astrocytic arborization and shrinkage of the astroglial domain, which may affect synaptic connectivity within the EC and between theEC and other brain regions.
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Complex and region-specific changes in astroglial markers in the aging brain.
José J. Rodríguez,José J. Rodríguez,Chia-Yu Yeh,Slavica Terzieva,M. Olabarria,Magdalena Kulijewicz-Nawrot,Alexei Verkhratsky,Alexei Verkhratsky,Alexei Verkhratsky +8 more
TL;DR: Based on the morphological analysis of 3 astroglial markers, it is concluded that astrocytes undergo a complex age-dependent remodeling in a brain region-specific manner.
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Voluntary running and environmental enrichment restores impaired hippocampal neurogenesis in a triple transgenic mouse model of Alzheimer's disease.
José J. Rodríguez,Harun N. Noristani,M. Olabarria,John S. Fletcher,T. D.D. Somerville,Chia-Yu Yeh,Alexei Verkhratsky +6 more
TL;DR: It is suggested that hippocampus of 3xTg-AD animals maintains the potential for cellular plasticity and increase in physical activity and/or cognitive experience enhances neurogenesis and provides a potential for stimulation of cognitive function in AD.
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Mossy Cells Control Adult Neural Stem Cell Quiescence and Maintenance through a Dynamic Balance between Direct and Indirect Pathways.
Chia-Yu Yeh,Brent Asrican,Jonathan Moss,Luis Quintanilla,Ting He,Xia Mao,Frédéric Cassé,Elias Gebara,Hechen Bao,Wei Lu,Nicolas Toni,Juan Song +11 more
TL;DR: This study identifies MCs as a critical stem cell niche component that dynamically controls adult NSC quiescence and maintenance under various MC activity states through a balance of direct glutamatergic and indirect GABAergic signaling onto rNSCs.