C
Chieko Kitada
Researcher at Takeda Pharmaceutical Company
Publications - 133
Citations - 12316
Chieko Kitada is an academic researcher from Takeda Pharmaceutical Company. The author has contributed to research in topics: Receptor & Peptide sequence. The author has an hindex of 48, co-authored 133 publications receiving 11776 citations.
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Journal ArticleDOI
Molecular properties of apelin: tissue distribution and receptor binding
Yuji Kawamata,Yugo Habata,Shoji Fukusumi,Masaki Hosoya,Ryo Fujii,Shuji Hinuma,Naoki Nishizawa,Chieko Kitada,Haruo Onda,Osamu Nishimura,Masahiko Fujino +10 more
TL;DR: It is found that the molecular forms of apelin differ among respective tissues: apelin molecules with sizes close to apelin-36 were major components in the lung, testis, and uterus, but both long and short forms were detected in the mammary gland.
Journal ArticleDOI
Molecular and Functional Characteristics of APJ TISSUE DISTRIBUTION OF mRNA AND INTERACTION WITH THE ENDOGENOUS LIGAND APELIN
Masaki Hosoya,Yuji Kawamata,Shoji Fukusumi,Ryo Fujii,Yugo Habata,Shuji Hinuma,Chieko Kitada,Susumu Honda,Tsutomu Kurokawa,Haruo Onda,Osamu Nishimura,Masahiko Fujino +11 more
TL;DR: The different patterns of acidification induced by these two peptides appeared to reflect their dissociation rather than association with APJ, which might have different functions in vivo and in vitro.
Journal ArticleDOI
Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum
Yugo Habata,Ryo Fujii,Masaki Hosoya,Shoji Fukusumi,Yuji Kawamata,Shuji Hinuma,Chieko Kitada,Naoki Nishizawa,Shinji Murosaki,Tsutomu Kurokawa,Haruo Onda,Kazuhiko Tatemoto,Masahiko Fujino +12 more
TL;DR: In the mammary gland of pregnant rats, biologically active apelin and its mRNA considerably increased during pregnancy and lactation, and reached a maximal level around parturition, and the oral intake of apelin in the colostrum and milk might modulate immune responses in neonates.
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Dramatic Elevation of Plasma Metastin Concentrations in Human Pregnancy: Metastin as a Novel Placenta-Derived Hormone in Humans
Yasuko Horikoshi,Hirokazu Matsumoto,Yoshihiro Takatsu,Tetsuya Ohtaki,Chieko Kitada,Satoshi Usuki,Masahiko Fujino +6 more
TL;DR: Evidence is provided for metastin as a novel placenta-derived hormone in humans and the major portion of the circulating metastin, as determined by the two-site enzyme immunoassay, represents endogenous metastin.
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A sensitive sandwich-enzyme immunoassay for human endothelin.
TL;DR: Preliminary investigations indicated that the basal level of immunoreactive endothelin in male plasma (n = 24) extracted with Seppak C-18 cartridges was 1.59 +/- 0.32 pg/ml.