[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

Guideline for Prevention of Surgical Site Infection, 1999 ☆ ☆☆ ★ ★★

The “Guideline for Prevention of Surgical Site Infection, 1999” presents the Centers for Disease Control and Prevention (CDC)'s recommendations for the prevention of surgical site infections (SSIs), formerly called surgical wound infections. This two-part guideline updates and replaces previous guidelines.Part I, “Surgical Site Infection: An Overview,” describes the epidemiology, definitions, microbiology, pathogenesis, and surveillance of SSIs. Included is a detailed discussion of the pre-, intra-, and postoperative issues relevant to SSI genesis.

/pdf/guideline-for-prevention-of-surgical-site-infection-1999-2k3en33kqw.pdf

Guideline for Prevention of Surgical Site Infection, 1999

http://www.mtdna.or.kr/neowiz/board/up_files/files_17/Chitin_Chitosan_polymers_chemistrySolubilityFiberFormation.pdf

Chitin and chitosan polymers: Chemistry, solubility and fiber formation

https://dash.harvard.edu/bitstream/handle/1/29293165/Cancer%20Nanotechnology.pdf?sequence=1

Cancer Nanotechnology: The impact of passive and active targeting in the era of modern cancer biology

Synthesis, characterization and controlled drug release of thermosensitive IPN-PNIPAAm hydrogels.

Redox/pH dual stimuli-responsive biodegradable nanohydrogels with varying responses to dithiothreitol and glutathione for controlled drug release

The purpose of this research was to synthesize new regular poly(ester amide)s (PEAs) consisting of nontoxic building blocks like hydrophobic α-amino acids, α,ω-diols, and aliphatic dicarboxylic acids, and to examine the effects of the structure of these building block components on some physico-chemical and biochemical properties of the polymers. PEAs were prepared by solution polycondensation of di-p-toluenesulfonic acid salts of bis-(α-amino acid) α,ω-alkylene diesters and di-p-nitrophenyl esters of diacids. Optimal conditions of this reaction have been studied. High molecular weight PEAs (Mw = 24,000–167,000) with narrow polydispersity (Mw/Mn = 1.20–1.81) were prepared under the optimal reaction conditions and exhibited excellent film-forming properties. PEAs obtained are mostly amorphous materials with Tg from 11 to 59°C. α-Chymotrypsin catalyzed in vitro hydrolysis of these new PEA substrates was studied to assess the effect of the building blocks of these new polymers on their biodegradation properties. © 1999 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 37: 391–407, 1999

Amino acid-based bioanalogous polymers. Synthesis, and study of regular poly(ester amide)s based on bis(?-amino acid) ?,?-alkylene diesters, and aliphatic dicarboxylic acids

The present invention provides elastomeric copolyester amides, elastomeric copolyester urethanes, and methods for making the same. The polymers that are based on α-amino acids and possess suitable physical, chemical and biodegradation properties. The polymers are useful as carriers of drugs or other bioactive substances. The polymers can be linked, intermixed, or a combination thereof, to one or more drugs.

Elastomeric functional biodegradable copolyester amides and copolyester urethanes

The hydrolytic degradation of polyglycolic acid (PGA) was studied by examining the changes of tensile strength and the level of crystallinity of the suture material. It was found that the breaking stress decreased from 6.369 × 10−1 at 0 day to 3.97 × 10−3 Newton/Tex at 49 days. The sigmodial shape of the stress–strain curves gradually disappeared with increase in the duration of in vitra degradation. The endpoint titration method used to assess the degree of degradation beyond the period of measurable tensile strength showed that the percent of PGA degraded were 42, 56, and 70% at 49, 60, and 90 days, respectively. The level of crystallinity of PGA at various durations of degradation exhibited an initial increase in the degree of crystallinity from 40% at 0 day to an upper limit of 52% at 21 days, then gradual decrease to 23% at 90 days. This observation is essentially parallel to hydrolysis of cellulose and polyethylene terephthalate. The concept of microfibrillar structure of fibers provides the basis for the proposed degradation mechanism of PGA in vitro. It is believed that degradation proceeds through two main stages which are different in rate of degradation.

Chih-Chang Chu

Papers

Synthesis, characterization and controlled drug release of thermosensitive IPN-PNIPAAm hydrogels.

Redox/pH dual stimuli-responsive biodegradable nanohydrogels with varying responses to dithiothreitol and glutathione for controlled drug release

Amino acid-based bioanalogous polymers. Synthesis, and study of regular poly(ester amide)s based on bis(?-amino acid) ?,?-alkylene diesters, and aliphatic dicarboxylic acids

Elastomeric functional biodegradable copolyester amides and copolyester urethanes

Hydrolytic degradation of polyglycolic acid: Tensile strength and crystallinity study