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Chih Hsien Chang
Researcher at National Yang-Ming University
Publications - 5
Citations - 188
Chih Hsien Chang is an academic researcher from National Yang-Ming University. The author has contributed to research in topics: Cancer cell & Epidermal growth factor receptor. The author has an hindex of 3, co-authored 5 publications receiving 76 citations.
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Journal ArticleDOI
pH‐Responsive PEG‐Shedding and Targeting Peptide‐Modified Nanoparticles for Dual‐Delivery of Irinotecan and microRNA to Enhance Tumor‐Specific Therapy
TL;DR: P pH-sensitive and peptide-modified liposomes and solid lipid nanoparticles designed for encapsulation of irinotecan and miR-200 exhibit positive therapeutic outcomes by inhibiting colorectal tumor growth and reducing systemic toxicity.
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Improving the anticancer effect of afatinib and microRNA by using lipid polymeric nanoparticles conjugated with dual pH-responsive and targeting peptides
Shu Ting Hong,Huaching Lin,Chen Shen Wang,Chih Hsien Chang,Anya Maan Yuh Lin,Anya Maan Yuh Lin,James Chih-Hsin Yang,Yu Li Lo +7 more
TL;DR: A nanoparticle formulation consisting of a polymer core to carry afatinib or miR-139, which is surrounded by lipids modified with a targeting ligand and a pH-sensitive penetrating peptide to improve the anticancer effect of cargos against CRC cells.
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PEG-coated nanoparticles detachable in acidic microenvironments for the tumor-directed delivery of chemo- and gene therapies for head and neck cancer.
Yu Li Lo,Chih Hsien Chang,Chen Shen Wang,Muh Hwa Yang,Anya Maan Yuh Lin,Anya Maan Yuh Lin,Ci Jheng Hong,Wei Hsuan Tseng +7 more
TL;DR: The therapeutic efficacy and safety of the proposed co-treatment outperformed the commercially available Onivyde and other formulations used in a SAS tumor-bearing mouse model and may be an innovative strategy for HNC treatment.
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Gene-editing by CRISPR–Cas9 in combination with anthracycline therapy via tumor microenvironment-switchable, EGFR-targeted, and nucleus-directed nanoparticles for head and neck cancer suppression
TL;DR: In this article, multi-functional nanoparticles modified with pH-sensitive epidermal growth factor receptor (EGFR)-targeting and nucleus-directed peptides were designed for the efficient delivery of HuR CRISPR and epirubicin to human tongue squamous carcinoma SAS cells and SAS tumor-bearing mice.
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Lipid polymeric nanoparticles modified with tight junction-modulating peptides promote afatinib delivery across a blood–brain barrier model
TL;DR: In this paper, the use of a lipid polymeric nanoparticle (LPN) modified with a tight junction-modulating peptide is explored to enhance Afa delivery across the BBB model of mouse brain-derived endothelial bEnd.3 cells.