C
Chih-Kuang Chen
Researcher at National Sun Yat-sen University
Publications - 62
Citations - 2490
Chih-Kuang Chen is an academic researcher from National Sun Yat-sen University. The author has contributed to research in topics: Gene delivery & Transfection. The author has an hindex of 24, co-authored 55 publications receiving 2012 citations. Previous affiliations of Chih-Kuang Chen include University at Buffalo & National Taiwan University.
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Journal ArticleDOI
Overcoming Nonviral Gene Delivery Barriers: Perspective and Future
TL;DR: This work presents the existing delivery barriers and summarize current vector-specific strategies to overcome said barriers, and focuses on the gene delivery barriers associated with the two most common classes of nonviral vectors, cationic-based lipids and polymers.
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Graphene–Gold Metasurface Architectures for Ultrasensitive Plasmonic Biosensing
Shuwen Zeng,Shuwen Zeng,Kandammathe Valiyaveedu Sreekanth,Jingzhi Shang,Ting Yu,Chih-Kuang Chen,Feng Yin,Dominique Baillargeat,Dominique Baillargeat,Philippe Coquet,Philippe Coquet,Ho-Pui Ho,Andrei V. Kabashin,Ken-Tye Yong,Ken-Tye Yong +14 more
TL;DR: Benefiting from extreme phase singularities of reflected light induced by strong plasmon-mediated energy confinements, the metasurface demonstrates a much-improved sensitivity to molecular bindings nearby and achieves an ultralow detection limit.
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Overcoming Gene-Delivery Hurdles: Physiological Considerations for Nonviral Vectors.
TL;DR: In this review, potential avenues towards improving the transition of gene-delivery technologies from in vitro assessment to human clinical therapy are evaluated.
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Polylactide-graft-doxorubicin nanoparticles with precisely controlled drug loading for pH-triggered drug delivery.
Yun Yu,Chih-Kuang Chen,Wing Cheung Law,Wing Cheung Law,Emily Weinheimer,Sanghamitra Sengupta,Paras N. Prasad,Chong Cheng +7 more
TL;DR: In vitro studies against MCF-7 breast cancer cells showed that the NPs can be readily taken up and result in enhanced therapeutic efficiency as compared to DOX·HCl, indicating their promising potential applications as anticancer nanomedicines.
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Well-defined degradable brush polymer-drug conjugates for sustained delivery of Paclitaxel.
TL;DR: To achieve a conjugated drug delivery system with high drug loading but minimal long-term side effects, a degradable brush polymer-drug conjugate (BPDC) was synthesized through azide-alkyne click reaction of acetylene-functionalized polylactide (PLA) withAzide- functionalized paclitaxel (PTXL) and poly(ethylene glycol) (PEG).