C
Ching-Ling Lien
Researcher at Children's Hospital Los Angeles
Publications - 64
Citations - 3879
Ching-Ling Lien is an academic researcher from Children's Hospital Los Angeles. The author has contributed to research in topics: Zebrafish & Regeneration (biology). The author has an hindex of 28, co-authored 59 publications receiving 3444 citations. Previous affiliations of Ching-Ling Lien include University of Texas Southwestern Medical Center & University of Texas at Dallas.
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Journal ArticleDOI
Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart.
Sean M. Wu,Yuko Fujiwara,Yuko Fujiwara,Susan M. Cibulsky,David E. Clapham,David E. Clapham,Ching-Ling Lien,Thomas M. Schultheiss,Stuart H. Orkin +8 more
TL;DR: Results support the existence of a common precursor for cardiovascular lineages in the mammalian heart by isolating Nkx2.5(+) cells from mouse embryos and demonstrating their capacity for bipotential differentiation in vivo.
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Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer
TL;DR: A cardiac enhancer is described, located about 9 kilobases upstream of the Nkx2-5 gene, that fully recapitulates the expression pattern of the endogenous gene in cardiogenic precursor cells from the onset of cardiac lineage specification and throughout the linear and looping heart tube.
Journal ArticleDOI
fgf20 is essential for initiating zebrafish fin regeneration.
TL;DR: The devoid of blastema (dob) mutant is characterized that fails fin regeneration during initial steps, forms abnormal regeneration epithelium, and does not form blastema.
Journal ArticleDOI
Gene Expression Analysis of Zebrafish Heart Regeneration
Ching-Ling Lien,Michael Schebesta,Michael Schebesta,Shinji Makino,Shinji Makino,Gerhard J. Weber,Mark T. Keating,Mark T. Keating +7 more
TL;DR: The data indicate that zebrafish heart regeneration is associated with sequentially upregulated wound healing genes and growth factors and suggest that PDGF signaling is required.
Journal ArticleDOI
Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration
Michaela Patterson,Lindsey Barske,Ben Van Handel,Christoph Rau,Peiheng Gan,Avneesh Sharma,Shan Parikh,Matt Denholtz,Ying Huang,Yukiko Yamaguchi,Hua Shen,Hooman Allayee,J. Gage Crump,Thomas Force,Ching-Ling Lien,Ching-Ling Lien,Takako Makita,Takako Makita,Aldons J. Lusis,S. Ram Kumar,Henry M. Sucov +20 more
TL;DR: The results corroborate the relevance of MNDCMs in heart regeneration and imply that intrinsic heart regeneration is not limited nor uniform in all individuals, but rather is a variable trait influenced by multiple genes.