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Chitra Lc Varanasi
Researcher at St. Vincent's Institute of Medical Research
Publications - 2
Citations - 48
Chitra Lc Varanasi is an academic researcher from St. Vincent's Institute of Medical Research. The author has contributed to research in topics: Downregulation and upregulation & Unfolded protein response. The author has an hindex of 2, co-authored 2 publications receiving 35 citations.
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Journal ArticleDOI
Lipotoxic Stress Induces Pancreatic β-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System.
Sara A Litwak,Jibran A Wali,Evan Pappas,Hamdi Saadi,William J Stanley,Chitra Lc Varanasi,Thomas W.H. Kay,Helen E. Thomas,Esteban Nicolas Gurzov +8 more
TL;DR: It is demonstrated that the FFA palmitate blocks the ubiquitin-proteasome system (UPS) and causes apoptosis through induction of ER stress and deregulation of Bcl-2 proteins, suggesting that targeting the UPS and BCl-2 protein expression may be a valuable strategy to prevent β-cell demise in type 2 diabetes.
Journal ArticleDOI
Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice
Jibran A Wali,Jibran A Wali,Sandra Galic,Christina Tan,Esteban Nicolas Gurzov,Ann Ae Frazier,Timothy Connor,Jingjing Ge,Evan G Pappas,David A. Stroud,Chitra Lc Varanasi,Claudia Selck,Michael T. Ryan,David Dr Thorburn,David Dr Thorburn,Bruce E. Kemp,Balasubramanian Krishnamurthy,Thomas W.H. Kay,Sean Sl McGee,Helen E. Thomas +19 more
TL;DR: A role for BIM in regulating mitochondrial bioenergetics and metabolism is suggested and the idea that regulation of metabolism and cell death are connected is supported.