C
Chiying An
Researcher at Harbin Medical University
Publications - 5
Citations - 177
Chiying An is an academic researcher from Harbin Medical University. The author has contributed to research in topics: Neuroprotection & Neuroinflammation. The author has an hindex of 3, co-authored 5 publications receiving 134 citations.
Papers
More filters
Journal ArticleDOI
The effect of cationic albumin-conjugated PEGylated tanshinone IIA nanoparticles on neuronal signal pathways and neuroprotection in cerebral ischemia
TL;DR: It is demonstrated that CBSA-PEG-TIIA-NPs displayed remarkable neuroprotective effects on ischemic stroke through modulation of MAPK signal pathways involved in the cascades of neuroinflammation.
Journal ArticleDOI
Protective effects of cationic bovine serum albumin-conjugated PEGylated tanshinone IIA nanoparticles on cerebral ischemia.
TL;DR: Cationic bovine serum albumin-conjugated tanshinone IIA PEGylated nanoparticles possessed remarkable neuroprotective effects on ischemic stroke through modulation of inflammatory cascades and neuronal signal pathways involved in cerebral ischemia.
Journal ArticleDOI
Protective Effect of Iridoid Glycosides of the Leaves of Syringa oblata Lindl. on Dextran Sulfate Sodium-Induced Ulcerative Colitis by Inhibition of the TLR2/4/MyD88/NF-κB Signaling Pathway.
Yifang Zhang,Dandan Han,Shen Yu,Chiying An,Xin Liu,Xin Liu,Haijing Zhong,Yuan Xu,Lianzhou Jiang,Zhongjiang Wang +9 more
TL;DR: It is demonstrated that IG exerts its inhibitory effect on cell apoptosis, oxidative stress, and proinflammatory cytokines in DSS-induced colitis through modulation of the TLR2/4/MyD88/NF-κB signaling pathway.
Journal ArticleDOI
Neutrophil-mediated and low density lipoprotein receptor-mediated dual-targeting nanoformulation enhances brain accumulation of scutellarin and exerts neuroprotective effects against ischemic stroke
Yanxin Dang,Chiying An,Yutao Li,Dandan Han,Xin Liu,Xin Liu,Feng-Ming Zhang,Yuan Xu,Haijing Zhong,Mewand Khan Karim Khan,Fengjuan Zou,Xiao-Jun Sun +11 more
TL;DR: The results suggest that this dual-targeting delivery system is a promising drug delivery vehicle for ischemic stroke, and possibly other CNS diseases where neuroinflammation is involved.
Journal ArticleDOI
Neutrophil affinity for PGP and HAIYPRH (T7) peptide dual-ligand functionalized nanoformulation enhances the brain delivery of tanshinone IIA and exerts neuroprotective effects against ischemic stroke by inhibiting proinflammatory signaling pathways
Yutao Li,Chiying An,Danan Han,Yanxin Dang,Xin Liu,Xin Liu,Feng-Ming Zhang,Yuan Xu,Haijing Zhong,Xiao-Jun Sun +9 more
TL;DR: A novel ischemic inflammatory site-recognizing and BBB-penetrating dual-targeting nano-drug system that has been proved to be a high-loading formulation for the neuroprotective compound, tanshinone IIA, and significantly improved its brain accumulation and therapeutic efficacy in a rodent model of isChemic stroke.