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Chloe J. Pugh
Researcher at University of Liverpool
Publications - 4
Citations - 166
Chloe J. Pugh is an academic researcher from University of Liverpool. The author has contributed to research in topics: Helix & Truncated tetrahedron. The author has an hindex of 3, co-authored 4 publications receiving 118 citations.
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Journal ArticleDOI
High-throughput discovery of organic cages and catenanes using computational screening fused with robotic synthesis
Rebecca L. Greenaway,Valentina Santolini,Michael J. Bennison,Ben M. Alston,Chloe J. Pugh,Marc A. Little,Marcin Miklitz,E. G. B. Eden-Rump,Rob Clowes,A. Shakil,H. J. Cuthbertson,H. Armstrong,Michael E. Briggs,Kim E. Jelfs,Andrew I. Cooper +14 more
TL;DR: Computational screening with high-throughput robotic synthesis is combined to create a hybrid discovery workflow for discovering new organic cage molecules, and by extension, other supramolecular systems that form cleanly in one-pot syntheses.
Journal ArticleDOI
Cage Doubling: Solvent-Mediated Re-equilibration of a [3 + 6] Prismatic Organic Cage to a Large [6 + 12] Truncated Tetrahedron
Chloe J. Pugh,Valentina Santolini,Rebecca L. Greenaway,Marc A. Little,Michael E. Briggs,Kim E. Jelfs,Andrew I. Cooper +6 more
TL;DR: It is shown that a [3 + 6] trigonal prismatic imine cage can rearrange stoichiometrically and structurally to form a [6 + 12] cage with a truncated tetrahedral shape.
Journal ArticleDOI
The simplest supramolecular helix
Felix Hanke,Chloe J. Pugh,Ellis Kay,Joshua B. Taylor,Stephen M. Todd,Craig M. Robertson,Benjamin J. Slater,Alexander Steiner +7 more
TL;DR: Structural studies and large scale sampling simulations show that the helical arrangement of Diethylamine is more stable than cyclic structures, which are the dominant species for other small hydrogen bonding molecules.
Journal ArticleDOI
The Helical Structure of Diallylamine in the Solid State
TL;DR: In the solid state diallylamine forms supramolecular helices with four molecules per pitch that are held together by hydrogen bonding as discussed by the authors, which is the result of competing length scales at which hydrogen bonding and second-neighbour Van-der-Waals interactions occur.