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Choi Lai Tiong
Researcher at ARIAD Pharmaceuticals, Inc.
Publications - 3
Citations - 1372
Choi Lai Tiong is an academic researcher from ARIAD Pharmaceuticals, Inc.. The author has contributed to research in topics: Proto-oncogene tyrosine-protein kinase Src & Fosmid. The author has an hindex of 3, co-authored 3 publications receiving 1330 citations.
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Journal ArticleDOI
Cloning the soil metagenome: a strategy for accessing the genetic and functional diversity of uncultured microorganisms.
Michelle R. Rondon,Paul R. August,Alan D. Bettermann,Sean F. Brady,Trudy H Grossman,Mark R. Liles,Kara A. Loiacono,Berkley A. Lynch,Ian A. MacNeil,Minor Charles A,Choi Lai Tiong,Michael Z. Gilman,Marcia S. Osburne,Jon Clardy,Jo Handelsman,Robert M. Goodman +15 more
TL;DR: Phylogenetic analysis of 16S rRNA gene sequences recovered from one of the libraries indicates that the BAC libraries contain DNA from a wide diversity of microbial phyla, including sequences from diverse taxa such as the low-G+C, gram-positive Acidobacterium,Cytophagales, and Proteobacteria.
Journal ArticleDOI
A Fluorescence Polarization Based Src-SH2 Binding Assay
TL;DR: An assay based on fluorescence polarization for measuring the binding of compounds to the Src-SH2 domain is described, which is insensitive to changes in fluorescence intensity working even in solutions with moderate optical density and functions in the presence of up to 20% dimethyl sulfoxide.
Journal ArticleDOI
Structure-activity relationships of a novel class of Src SH2 inhibitors
John L. Buchanan,Chi B. Vu,Taylor Merry,Evelyn G. Corpuz,Selvaluxmi G. Pradeepan,Ukti Mani,Michael Yang,Hilary R. Plake,Vaibhav Varkhedkar,Berkley A. Lynch,Ian A. MacNeil,Kara A. Loiacono,Choi Lai Tiong,Dennis A. Holt +13 more
TL;DR: The structure-activity relationships (SAR) of a novel class of Src SH2 inhibitors are described, which resulted in inhibitors that bound as well as the standard tetrapeptide Ac-pYEEI-NH2.