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Chongyun Fang
Researcher at University of Pennsylvania
Publications - 7
Citations - 1801
Chongyun Fang is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Chimeric antigen receptor & Antigen. The author has an hindex of 6, co-authored 6 publications receiving 1360 citations.
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Journal ArticleDOI
Multiplex Genome Editing to Generate Universal CAR T Cells Resistant to PD1 Inhibition
TL;DR: Gene-disrupted allogeneic CAR and TCR T cells could provide an alternative as a universal donor to autologous T cells, which carry difficulties and high production costs.
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Affinity-Tuned ErbB2 or EGFR Chimeric Antigen Receptor T Cells Exhibit an Increased Therapeutic Index against Tumors in Mice
Xiaojun Liu,Shuguang Jiang,Chongyun Fang,Shiyu Yang,Devvora Olalere,Edward Pequignot,Alexandria P. Cogdill,Na Li,Melissa Ramones,Brian Granda,Li Zhou,Andreas Loew,Regina M. Young,Carl H. June,Yangbing Zhao +14 more
TL;DR: The use of affinity-tuned scFvs offers a strategy to empower wider use of CAR T cells against validated targets widely overexpressed on solid tumors, including those considered undruggable by this approach.
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A Chimeric Switch-Receptor Targeting PD1 Augments the Efficacy of Second-Generation CAR T Cells in Advanced Solid Tumors
Xiaojun Liu,Raghuveer Ranganathan,Shuguang Jiang,Chongyun Fang,Jing Sun,Soyeon Kim,Kheng Newick,Albert C. Lo,Carl H. June,Yangbing Zhao,Edmund K. Moon +10 more
TL;DR: The findings suggest that the application of PD1CD28 to boost CAR T-cell activity is efficacious against solid tumors via a variety of mechanisms, prompting clinical investigation of this potentially promising treatment modality.
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A versatile system for rapid multiplex genome-edited CAR T cell generation
Jiangtao Ren,Xuhua Zhang,Xiaojun Liu,Chongyun Fang,Shuguang Jiang,Carl H. June,Yangbing Zhao +6 more
TL;DR: This study accomplished rapid and efficient multiplex genomic editing, and re-directing T cells with antigen specific CAR via a one-shot CRISPR protocol by incorporation of multiple gRNAs in a CAR lentiviral vector.
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Novel T cells with improved in vivo anti-tumor activity generated by RNA electroporation
Xiaojun Liu,Shuguang Jiang,Chongyun Fang,Hua Li,Xuhua Zhang,Fuqin Zhang,Carl H. June,Yangbing Zhao +7 more
TL;DR: T cells with both a less differentiated phenotype and potent tumor killing ability can be generated by RNA electroporation, and this T cell manufacturing procedure can be further optimized by simply co-delivering other splices of RNA, thus providing a simple and cost-effective method for generating high-quality T cells for adoptive immunotherapy.