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Christa Merzdorf
Researcher at Montana State University
Publications - 18
Citations - 585
Christa Merzdorf is an academic researcher from Montana State University. The author has contributed to research in topics: Neural plate & Neural fold. The author has an hindex of 9, co-authored 17 publications receiving 537 citations. Previous affiliations of Christa Merzdorf include Massachusetts Institute of Technology.
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Journal ArticleDOI
Opl : a zinc finger protein that regulates neural determination and patterning in xenopus
John S. Kuo,Mukesh Patel,Joshua T. Gamse,Christa Merzdorf,Xuedong Liu,Vladimir Apekin,Hazel Sive +6 more
TL;DR: Together, data suggest that opl may mediate neural competence and may be involved in activation of midbrain, dorsal neural and neural crest fates.
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Emerging roles for zic genes in early development
TL;DR: This review summarizes knowledge of the molecular events that govern the activities of zic family members, including emerging relationships between upstream signaling pathways and zic genes, and advancements in the understanding of the Molecular events downstream of Zic transcription factors are reviewed.
Journal ArticleDOI
Formation of functional tight junctions in Xenopus embryos.
TL;DR: Tight junctions before the 64-cell stage were not at their normal apical positions, but were found deep in the embryos, up to 200 micron from the apical surface, explaining why electrophysiological experiments record a decrease in embryonic input resistances concomitant with early cleavage stages.
Journal ArticleDOI
The zic1 gene is an activator of Wnt signaling
Christa Merzdorf,Hazel Sive +1 more
TL;DR: It is demonstrated that an active Wnt pathway is required for activation of en-2 expression by zic1, and that the regulatory relationships between opa, wingless and engrailed seen in Drosophila are also present in vertebrates.
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Gain-of-Function Mutations in ZIC1 Are Associated with Coronal Craniosynostosis and Learning Disability.
Stephen R.F. Twigg,Jennifer Forecki,Jacqueline A C Goos,Ivy C.A. Richardson,A. Jeannette M. Hoogeboom,Ans M.W. van den Ouweland,Sigrid M. A. Swagemakers,Maarten H. Lequin,Daniel J. Van Antwerp,Simon J. McGowan,Isabelle Westbury,Kerry A. Miller,Steven A. Wall,Peter J. van der Spek,Irene M.J. Mathijssen,Erwin Pauws,Christa Merzdorf,Andrew O.M. Wilkie +17 more
TL;DR: It is concluded that the human mutations uncover a previously unsuspected role for Zic1 in early cranial suture development, potentially by regulating engrailed 1, which was previously shown to be critical for positioning of the murine coronal suture.