C
Christian Bonnerot
Researcher at Curie Institute
Publications - 61
Citations - 7538
Christian Bonnerot is an academic researcher from Curie Institute. The author has contributed to research in topics: Receptor & Antigen presentation. The author has an hindex of 34, co-authored 61 publications receiving 6994 citations. Previous affiliations of Christian Bonnerot include French Institute of Health and Medical Research & Pasteur Institute.
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Journal ArticleDOI
Exosomal-like vesicles are present in human blood plasma.
Marie-Pierre Caby,Danielle Lankar,Claude Vincendeau-Scherrer,Graça Raposo,Christian Bonnerot +4 more
TL;DR: It is demonstrated that blood is a physiological fluid for exosome circulation in the body, suggesting their role in cell-cell or organ-organ communications as carriers for molecules that need to reach distant cell targets.
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Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial
Bernard Escudier,Thierry Dorval,Nathalie Chaput,Fabrice Andre,Marie-Pierre Caby,Sophie Novault,Caroline Flament,Christophe Leboulaire,Christophe Borg,Sebastian Amigorena,Catherine Boccaccio,Christian Bonnerot,Olivier Dhellin,Mojgan Movassagh,Sophie Piperno,Caroline Robert,Vincent Serra,Nancy Valente,Jean-Bernard Le Pecq,Alain Spatz,Olivier Lantz,Thomas Tursz,Eric Angevin,Laurence Zitvogel +23 more
TL;DR: The first exosome Phase I trial highlighted the feasibility of large scale exosomal MHC class II molecules production and the safety of exosomes administration.
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Fcγ Receptor–mediated Induction of Dendritic Cell Maturation and Major Histocompatibility Complex Class I–restricted Antigen Presentation after Immune Complex Internalization
Armelle Regnault,Danielle Lankar,Valérie Lacabanne,Ana Rodriguez,Clotilde Théry,Maria Rescigno,Takashi Saito,J. Sjef Verbeek,Christian Bonnerot,Paola Ricciardi-Castagnoli,Sebastian Amigorena +10 more
TL;DR: It is shown that FcγRs have two additional specific attributes in murine DCs: the induction of DC maturation and the promotion of efficient MHC class I–restricted presentation of peptides from exogenous, IgG-complexed antigens.
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Mast cell- and dendritic cell-derived exosomes display a specific lipid composition and an unusual membrane organization
Karine Laulagnier,Claude Motta,Safouane M. Hamdi,Sébastien Roy,Florence Fauvelle,Jean-François Pageaux,Toshihide Kobayashi,Jean-Pierre Salles,Bertrand Perret,Christian Bonnerot,Michel Record +10 more
TL;DR: Exosome membrane displays a similar content of the major phospholipids and cholesterol, and is organized as a lipid bilayer with a random distribution of phosphatidylethanolamines, and observed tight lipid packing at neutral pH and a rapid flip-flop between the two leaflets of exosome membranes.
Journal ArticleDOI
Cytoplasmic domain heterogeneity and functions of IgG Fc receptors in B lymphocytes.
Sebastian Amigorena,Christian Bonnerot,James R. Drake,Daniel Choquet,Walter Hunziker,Jean-Gérard Guillet,Paul Webster,Catherine Sautes,Ira Mellman,Wolf H. Fridman +9 more
TL;DR: The insertion was not required for Fc gamma RII to modulate surface immunoglobulin-triggered B-cell activation, but did contribute to the formation of caps in response to receptor cross-linking, consistent with suggestions that the lymphocyte but not macrophage form of the receptor can associate with the detergent-insoluble cytoskeleton.