C
Christian Kersten
Researcher at University of Mainz
Publications - 25
Citations - 159
Christian Kersten is an academic researcher from University of Mainz. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 3, co-authored 12 publications receiving 49 citations. Previous affiliations of Christian Kersten include University of Bergen.
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Journal ArticleDOI
Proline-Based Allosteric Inhibitors of Zika and Dengue Virus NS2B/NS3 Proteases
Benedikt Millies,Franziska von Hammerstein,Andrea Gellert,Stefan Hammerschmidt,Fabian Barthels,Ulrike Göppel,Melissa Immerheiser,Fabian Elgner,Nathalie Jung,Michael Basic,Christian Kersten,Werner Kiefer,Jochen Bodem,Eberhard Hildt,Maike Windbergs,Ute A. Hellmich,Ute A. Hellmich,Tanja Schirmeister +17 more
TL;DR: A novel inhibitor scaffold targeting an allosteric site shared between flaviviral NS2B/NS3 proteases is presented whose efficacy is demonstrated in vitro and in cellulo.
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Structure-Activity Relationships of Benzamides and Isoindolines Designed as SARS-CoV Protease Inhibitors Effective against SARS-CoV-2.
Armin Welker,Christian Kersten,Christin Müller,Ramakanth Madhugiri,Collin Zimmer,Patrick Müller,Robert A. Zimmermann,Stefan Hammerschmidt,Hannah Maus,John Ziebuhr,Christoph A. Sotriffer,Tanja Schirmeister +11 more
TL;DR: In this paper, the structure-activity relationship (SAR) of the noncovalent active-site directed inhibitor (R)-5-amino-2-methyl-N-(1-(naphthalen-1-yl)ethyl) benzamide (2 b) is reported.
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Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure-Activity Relationship, Inhibition Mechanism, Metabolism, and In Vivo Studies.
Sascha Jung,Natalie Fuchs,Patrick Johe,Annika Wagner,Erika Diehl,Tri Yuliani,Collin Zimmer,Fabian Barthels,Robert A. Zimmermann,Philipp Klein,Waldemar Waigel,Jessica Meyr,Till Opatz,Stefan Tenzer,Ute Distler,Hans Joachim Räder,Christian Kersten,Bernd Engels,Ute A. Hellmich,Ute A. Hellmich,Jochen Klein,Tanja Schirmeister +21 more
TL;DR: In this article, α-fluorovinylsulfones/-sulfonates were optimized for rhodesain based on molecular modeling approaches, and 2d, the most potent and selective inhibitor in the series, showed a single-digit nanomolar affinity and high selectivity toward mammalian cathepsins B and L.
Journal ArticleDOI
BANΔIT: B'-factor Analysis for Drug Design and Structural Biology.
TL;DR: A JavaScript‐based browser application that provides a graphical user interface for the normalization and analysis of B'‐factor profiles and has given exemplary conclusions for further drug optimization including the development of a B’‐factor‐supported pharmacophore model for SARS CoV‐2 main protease inhibitors.
Journal ArticleDOI
Structure, interdomain dynamics, and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes.
Patrick Johe,Elmar Jaenicke,Hannes Neuweiler,Tanja Schirmeister,Christian Kersten,Ute A. Hellmich,Ute A. Hellmich +6 more
TL;DR: In this article, the trypanosomal cathepsin L-like cysteine protease of Trypanosoma brucei rhodesiense, the causative agent of Human African T.