Stefan Tenzer

TL;DR: It is shown that label-free snapshot proteomics can be used to obtain quantitative time-resolved profiles of human plasma coronas formed on silica and polystyrene nanoparticles of various size and surface functionalization.

TL;DR: The complexity of the plasma corona is demonstrated and its still unresolved physicochemical regulation is demonstrated, which need to be considered in nanobioscience in the future.

TL;DR: A critical function of caspase-8 is demonstrated in regulating intestinal homeostasis and in protecting IECs from TNF-α-induced necroptotic cell death and high levels of RIP3 in human Paneth cells and increased ne croptosis in the terminal ileum of patients with Crohn’s disease are identified, suggesting a potential role of necropsies in the pathogenesis of this disease.

TL;DR: Differentially analyzed the protein corona composition on four polymeric differently functionalized nanoparticles by label-free quantitative mass spectrometry to identify key candidates for nanoparticle-protein interactions and correlated the relative abundance of identified proteins in the corona with enhanced or decreased cellular uptake.

TL;DR: C cultured oligodendrocytes secrete exosomes carrying major amounts of PLP and 2′3′‐cyclic‐nucleotide‐phosphodiesterase (CNP), together with a striking group of proteins with proposed functions in the relief of cell stress.