C
Christian R. Frey
Publications - 2
Citations - 393
Christian R. Frey is an academic researcher. The author has contributed to research in topics: Viral load & Receptor. The author has an hindex of 2, co-authored 2 publications receiving 353 citations.
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Journal ArticleDOI
GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees
Robert E. Lanford,Bernadette Guerra,Deborah Chavez,Luis D. Giavedoni,Vida L. Hodara,Kathleen M. Brasky,Abigail Fosdick,Christian R. Frey,Jim Zheng,Grushenka H.I. Wolfgang,Randall L. Halcomb,Daniel B. Tumas +11 more
TL;DR: The small molecule GS-9620 activates Toll-like receptor 7 signaling in immune cells of chimpanzees to induce clearance of HBV-infected cells and might be developed for treatment of patients with chronic HBV infection.
Journal ArticleDOI
Safety, pharmacokinetics and pharmacodynamics of GS-9620, an oral Toll-like receptor 7 agonist.
Uri Aryeh Lopatin,Grushenka H.I. Wolfgang,Daniel B. Tumas,Christian R. Frey,Carol Ohmstede,Joseph Hesselgesser,Brian P. Kearney,Lisa Moorehead,G. Mani Subramanian,John G. McHutchison +9 more
TL;DR: GS-9620 demonstrates safety and pharmacodynamic activity at doses up to 12 mg, suggesting the potential for induction of an antiviral response without systemic adverse events in subjects with chronic viral hepatitis.