GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees
Robert E. Lanford,Bernadette Guerra,Deborah Chavez,Luis D. Giavedoni,Vida L. Hodara,Kathleen M. Brasky,Abigail Fosdick,Christian R. Frey,Jim Zheng,Grushenka H.I. Wolfgang,Randall L. Halcomb,Daniel B. Tumas +11 more
TLDR
The small molecule GS-9620 activates Toll-like receptor 7 signaling in immune cells of chimpanzees to induce clearance of HBV-infected cells and might be developed for treatment of patients with chronic HBV infection.About:
This article is published in Gastroenterology.The article was published on 2013-06-01 and is currently open access. It has received 342 citations till now. The article focuses on the topics: Hepatitis B virus & Natural killer cell activation.read more
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Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update.
Shiv Kumar Sarin,Manoj Kumar,George K. K. Lau,Zaigham Abbas,Henry Lik-Yuen Chan,Chien-Jen Chen,Ding-Shinn Chen,Huey-Ling Chen,Pei-Jer Chen,Rong-Nan Chien,Abdul Kadir Dokmeci,Edward Gane,J L Hou,Wasim Jafri,Jidong Jia,J. H. Kim,Ching-Lung Lai,Hon Cheung Lee,Seng Gee Lim,Chun-Jen Liu,Stephen Locarnini,M. Al Mahtab,Rosmawati Mohamed,Masao Omata,Jun Yong Park,Teerha Piratvisuth,Barjesh Chander Sharma,Jose D. Sollano,Fu-Sheng Wang,Lai Wei,Man-Fung Yuen,Shusen Zheng,Jia-Horng Kao +32 more
TL;DR: The final clinical practice guidelines and recommendations for the optimal management of chronic HBV infection are presented here, along with the relevant background information.
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Immunology in the liver — from homeostasis to disease
Felix Heymann,Frank Tacke +1 more
TL;DR: The liver is a central immunological organ with a high exposure to circulating antigens and endotoxins from the gut microbiota, particularly enriched for innate immune cells (macrophages, innate lymphoid cells, mucosal-associated invariant T (MAIT) cells) as mentioned in this paper.
Journal ArticleDOI
HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B
TL;DR: This review aims to summarise current knowledge on ccc DNA molecular biology, to highlight the experimental restrictions that have hitherto hampered faster progress and to discuss cccDNA as target for new, potentially curative therapies of chronic hepatitis B.
Journal ArticleDOI
Hepatitis B cure: From discovery to regulatory approval
TL;DR: Development of standardised assays for novel biomarkers toward better defining hepatitis B virus cure should occur in parallel with development of novel antiviral and immune modulatory therapies such that approval of new treatments can be linked to the approval ofnew diagnostic assays used to measure efficacy or to predict response.
Journal ArticleDOI
Therapeutic strategies for hepatitis B virus infection: towards a cure
TL;DR: Advances in hepatitis B therapies and challenges for their development are reviewed, including antiviral and immune-boosting strategies that could be part of combination strategies to achieve functional cure.
References
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Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.
Hiroaki Hemmi,Tsuneyasu Kaisho,Osamu Takeuchi,Shintaro Sato,Hideki Sanjo,Katsuaki Hoshino,Takao Horiuchi,Hideyuki Tomizawa,Kiyoshi Takeda,Shizuo Akira +9 more
TL;DR: It is shown that the imidazoquinolines activate immune cells via the Toll-like receptor 7 (TLR7)-MyD88–dependent signaling pathway, and that neither MyD88- nor TLR7-deficient mice showed any inflammatory cytokine production by macrophages, proliferation of splenocytes or maturation of dendritic cells.
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TL;DR: Recent progress on the characterization of plasmacytoid dendritic cell origin, development, migration and function in immunity and tolerance, as well as their effect on human diseases are reviewed.
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Immunology of hepatitis B virus and hepatitis C virus infection.
TL;DR: This review assesses recent advances in the understanding of viral hepatitis, contrasts mechanisms of virus–host interaction in acute hepatitis B and hepatitis C, and outlines areas for future studies.
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Viral Clearance Without Destruction of Infected Cells During Acute HBV Infection
Luca G. Guidotti,Rosemary Rochford,Josan Chung,Max Shapiro,Robert H. Purcell,Francis V. Chisari +5 more
TL;DR: Results demonstrate that noncytopathic antiviral mechanisms contribute to viral clearance during acute viral hepatitis by purging HBV replicative intermediates from the cytoplasm and covalently closed circular viral DNA from the nucleus of infected cells.
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Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists.
TL;DR: The identification of the antigen recognition receptors for innate immunity, most notably the Toll-like receptors, has sparked great interest in therapeutic manipulation of the innate immune system and significant efforts have begun to develop antagonists to Toll- like receptors.
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