C
Christian Ramakers
Researcher at Erasmus University Medical Center
Publications - 46
Citations - 6970
Christian Ramakers is an academic researcher from Erasmus University Medical Center. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 15, co-authored 22 publications receiving 6301 citations. Previous affiliations of Christian Ramakers include Maastricht University & University of Amsterdam.
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Journal ArticleDOI
Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data.
TL;DR: It is shown that the first approach can lead to PCR efficiencies that vary over a 0.2 range, whereas the second approach may be off by 0.26, and proposed linear regression on the Log(fluorescence) per cycle number data as an assumption-free method to calculate starting concentrations of mRNAs and PCRefficiencies for each sample.
Journal ArticleDOI
Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data
Jan M. Ruijter,Christian Ramakers,W. M. H. Hoogaars,Yann Karlen,O. Bakker,M. J. B. Van Den Hoff,Antoon F.M. Moorman +6 more
TL;DR: This article showed that baseline estimation errors are directly reflected in the observed PCR efficiency values and are thus propagated exponentially in the estimated starting concentrations as well as 'fold-difference' results.
Journal ArticleDOI
Mindfulness-based stress reduction and physiological activity during acute stress : A randomized controlled trial
Ivan Nyklíček,Paula M.C. Mommersteeg,Sylvia van Beugen,Christian Ramakers,Geert J.M. van Boxtel +4 more
TL;DR: MBSR may help reducing blood pressure levels and blood pressure reactivity to stress as well as reducing cardiovascular and cortisol activity during acute stress.
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Asynchronous development of electrical remodeling and cardiac hypertrophy in the complete AV block dog.
Marieke Schoenmakers,Christian Ramakers,Jurren M. van Opstal,Jet D. M. Leunissen,Camila Londoño,Marc A. Vos +5 more
TL;DR: In the CAVB dog ventricular hypertrophy is not a prerequisite for electrical remodeling or drug-induced torsade de pointes, and the AT1-receptor has no dominant role in the completion of these remodeling processes.
Journal ArticleDOI
Coordinated down-regulation of KCNQ1 and KCNE1 expression contributes to reduction of IKs in canine hypertrophied hearts
Christian Ramakers,Marc A. Vos,Pieter A. Doevendans,M Schoenmakers,Y.S Wu,S Scicchitano,A Iodice,George Thomas,Charles Antzelevitch,Robert Dumaine +9 more
TL;DR: The data suggest that electrical remodeling of the cardiac ventricle during hypertrophy involves regulation of the gene expression through modulation of transcriptional and translational regulatory pathways and may potentiate the action of Class III antiarrhythmic agents.