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Showing papers in "Neuroscience Letters in 2003"


Journal ArticleDOI
TL;DR: It is shown that the first approach can lead to PCR efficiencies that vary over a 0.2 range, whereas the second approach may be off by 0.26, and proposed linear regression on the Log(fluorescence) per cycle number data as an assumption-free method to calculate starting concentrations of mRNAs and PCRefficiencies for each sample.

3,536 citations


Journal ArticleDOI
TL;DR: The aim of the present study was to demonstrate the first time the non-invasive restoration of hand grasp function in a tetraplegic patient by electroencephalogram (EEG)-recording and functional electrical stimulation (FES) using surface electrodes.

542 citations


Journal ArticleDOI
TL;DR: The addition of vitamin D(3) significantly decreases the percentage of cultured hippocampal cells undergoing mitosis in conjunction with increases in both neurite outgrowth and NGF production, in developing neurons.

312 citations


Journal ArticleDOI
TL;DR: Marked microglial activation with minimal astrocytosis is another pathological feature of PD reproduced by rotenone treatment, and marked microglia enlarged and developed short, stubby processes in roten one-treated animals.

289 citations


Journal ArticleDOI
TL;DR: It is concluded that older adults rely more on their hip muscles when responding to self induced perturbations introduced by increased task constraints during quiet standing.

272 citations


Journal ArticleDOI
TL;DR: Men showed a stronger brain activity for positive visual stimuli than women in the frontal lobe (inferior and medial frontal gyrus) and in women, stronger brain activation for affectively negative pictures was observed in the anterior and medial cingulate gyrus.

270 citations


Journal ArticleDOI
TL;DR: Men showed significantly stronger parietal activation, while women showed significantly greater right frontal activation in functional magnetic resonance imaging, pointing to gender specific differences in the neuropsychological processes involved in mental rotation tasks.

254 citations


Journal ArticleDOI
TL;DR: The notion that sleepiness is directly represented in the awake EEG is supported, with strong negative correlations of alpha (8-12 Hz) power with subjective sleepiness at all scalp locations, suggesting a negative association between sleepiness and general cortical activation.

252 citations


Journal ArticleDOI
TL;DR: The data indicate that PPARalpha agonists protect the brain through PPARAlpha, and resveratrol and fenofibrate failed to protect thebrain in PPAR alpha knockout mice.

225 citations


Journal ArticleDOI
TL;DR: RTMS induced a significant improvement of visuo-spatial performance that remained quite unchanged 15 days after, and performance at Time 3 and 4 improved also as concerns line bisection and clock drawing tasks.

215 citations


Journal ArticleDOI
TL;DR: Neprilysin to decrease cerebral Abeta is suggested to be inevitable factor as a vital therapeutic target and degraded not only monomeric but also oligomeric forms of Abeta1-40, a significant Abeta species in early pathogenesis.

Journal ArticleDOI
TL;DR: Comparing the intensity-time curves for the two tumor groups, the PCNSL showed a characteristic type of curve with a significant increase in signal intensity above the baseline due to massive leakage of contrast media into the interstitial space.

Journal ArticleDOI
TL;DR: Results indicate the use of a feedback rather than a feed-forward mode of control in children with autism, which could explain the deficient postural anticipation reported inChildren with autism.

Journal ArticleDOI
TL;DR: Data indicate that the effect of melatonin in the TST seems to be mediated through an interaction with NMDA receptors and the L-arginine-NO pathway.

Journal ArticleDOI
TL;DR: The magnitude of the phase shifts in the melatonin acrophase and offset were similar after white and short wavelength light exposure, which suggests short wavelength sensitivity of the photoreceptors mediating synchronization of human circadian rhythms.

Journal ArticleDOI
TL;DR: It is shown that a normal function of α-synuclein is the negative modulation of human dopamine transporter (hDAT) activity, and under normal (non-toxic) expression conditions, α- Synuclein negatively modulates dopamine uptake by DAT.

Journal ArticleDOI
TL;DR: These findings show that transplanted human neural stem cells differentiate into mature neurons to replace lost neural cells in the adult hippocampus with human-rat neural chimeras.

Journal ArticleDOI
TL;DR: Observations suggest that glucocorticoids induce a more differentiated BBB phenotype in cultured brain endothelial cells through modification of tight junction structure.

Journal ArticleDOI
TL;DR: This study confirms the role of the amygdala in fear processing and provides insights into brain activation patterns when animal phobics are confronted with phobia-related stimuli.

Journal ArticleDOI
TL;DR: The results indicate a moderate beneficial effect of oral CoQ(10) supplementation in PD patients, and indicate a mild symptomatic benefit on PD symptoms and a significantly better improvement of FMT performance compared with placebo.

Journal ArticleDOI
TL;DR: A linearly increasing desynchronization in the upper alpha band with ascending cognitive load is found, and evidence of the involvement of distinguishable cognitive components in the memory tasks is found.

Journal ArticleDOI
TL;DR: The basal expression of VEGF and of several of its receptor mRNAs indicates a hitherto unknown angiogenic potential of neural stem cells.

Journal ArticleDOI
TL;DR: Administration of the cannabinoid CB1 receptor antagonist SR141716 abolished neuropeptide Y-induced overeating and significantly reduced ethanol and sucrose intake in CB1 wild-type (+/+) mice.

Journal ArticleDOI
TL;DR: This study suggests that the VVC inputs are processed in different pathways causing subjective autonomic symptoms and postural instability in humans.

Journal ArticleDOI
TL;DR: It is shown that a combination of three cerebrospinal fluid biochemical markers, total-tau, phospho-t Tau and beta-amyloid, can detect incipient AD among patients fulfilling the criteria for MCI with a sensitivity of 68% and a specificity of 97%.

Journal ArticleDOI
TL;DR: The central administration of ghrelin suppresses energy expenditure and thermogenesis in BAT via its inhibitory effect on BAT sympathetic nerve activity, which, in turn, affects adiposity and body weight.

Journal ArticleDOI
TL;DR: Evidence is provided of a possible role for apelin-13 in the control of food intake after intravenous (IV) and intracerebroventricular (ICV) injection in the Wistar rat.

Journal ArticleDOI
TL;DR: Event-related potentials were used to examine the role of grammatical gender in auditory sentence comprehension, and a similar negativity to prior articles of gender opposite to that of the contextually expected noun suggests that listeners predict specific words during comprehension.

Journal ArticleDOI
TL;DR: The findings suggest that the sensorimotor processing during FES involves some of the processes which are also involved in voluntary hand movements.

Journal ArticleDOI
TL;DR: Although the COMT Val158Met genetic polymorphism may play a role in cognitive function, ethnicity and testing method may affect the association, the results demonstrate that subjects bearing the Met/Met homozygote have significantly lower mean P300 latencies than do analogs bearing the Val allele.