C
Christian Renault
Researcher at Rhône-Poulenc
Publications - 60
Citations - 2312
Christian Renault is an academic researcher from Rhône-Poulenc. The author has contributed to research in topics: PK-11195 & Alkyl. The author has an hindex of 20, co-authored 60 publications receiving 2292 citations.
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Journal ArticleDOI
Peripheral benzodiazepine binding sites: effect of PK 11195, 1-(2-chlorophenyl)-N-methyl-(1-methylpropyl)-3 isoquinolinecarboxamide. II. In vivo studies.
G. Le Fur,M.L. Perrier,Nadine Vaucher,F. Imbault,A. Flamier,J. Benavides,Andre Uzan,Christian Renault,Marie-Christine Dubroeucq,C. Gueremy +9 more
TL;DR: In this article, a new compound, chemically unrelated to benzodiazepines, which is a potent inhibitor of [ 3 H] R05-4864 in vitro is also very effective after I.P. injection and oral administration.
Journal ArticleDOI
Peripheral benzodiazepine binding sites: Effect of PK 11195, 1-(2-chlorophenyl)-n-methyl-n-(1-methylpropyl)-3-isoquinolinecarboxamide
G. Le Fur,M.L. Perrier,Nadine Vaucher,F. Imbault,A. Flamier,J. Benavides,Andre Uzan,Christian Renault,Marie-Christine Dubroeucq,C. Gueremy +9 more
Journal ArticleDOI
Labelling of "peripheral-type" benzodiazepine binding sites in the rat brain by using [3H]PK 11195, an isoquinoline carboxamide derivative: kinetic studies and autoradiographic localization.
J. Benavides,D. Quarteronet,F. Imbault,C. Malgouris,Andre Uzan,Christian Renault,Marie-Christine Dubroeucq,C. Gueremy,G. Le Fur +8 more
TL;DR: PK 11195 [1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide] is a new ligand for the "peripheral-type" benzodiazepine binding sites, chemically unrelated to benzodiazines as mentioned in this paper.
Journal ArticleDOI
Differentiation between two ligands for peripheral benzodiazepine binding sites, [3H]R05-4864 and [3H]PK 11195, by thermodynamic studies
G. Le Fur,Nadine Vaucher,M.L. Perrier,A. Flamier,J. Benavides,Christian Renault,Marie-Christine Dubroeucq,C. Gueremy,Andre Uzan +8 more
TL;DR: In this paper, the binding sites in rat cardiac membranes are saturable, with high affinity, specific GABA-independent and correspond to the peripheral type of benzodiazepine, and the order of potency of displacing agents was: PK 11195 greater than RO5-4864 greater than dipyridamole greater than diazepam greater than clonazepam.
Journal ArticleDOI
Electrophysiological and pharmacological evidence that peripheral type benzodiazepine receptors are coupled to calcium channels in the heart
M. Mestre,T. Carriot,C. Belin,Andre Uzan,Christian Renault,Marie-Christine Dubroeucq,C. Gueremy,Adam Doble,G. Le Fur +8 more
TL;DR: The results suggest that in the heart the peripheral type benzodiazepine receptors are coupled to calcium channels.