Showing papers in "Life Sciences in 1983"

TL;DR: Of the groups studied, impulsive violent offenders who had attempted suicide had the lowest 5HIAA levels, which may be a marker of impulsivity rather than violence.

TL;DR: In this article, a new compound, chemically unrelated to benzodiazepines, which is a potent inhibitor of [ 3 H] R05-4864 in vitro is also very effective after I.P. injection and oral administration.

TL;DR: Findings indicate that noradrenergic hyperactivity may be a factor in the production of some anxiety states and the anti-anxiety effects of clonidine appear to result from its actions on receptors which decrease nor adrenergic activity.

TL;DR: Findings indicate that CV-3988 specifically inhibits the action of PAF in vitro and in vivo, the first report of a PAF antagonist which can specifically inhibit the PAf-induced hypotension as well as the PAF-induced platelet aggregation.

TL;DR: A new benzothiophene derived antiestrogen, LY139481, inhibited the uterotropic action of Estradiol in a dose related fashion, and at 1 mg per day suppressed more than 90 percent of estradiol's activity in immature rats.

TL;DR: This mini-review attempts to highlight major recent developments underlying the current situation and the possibility that generation of toxic products of lipid peroxidation may act as toxicological "second messengers" linking events near cytochrome P-450 to distant parts of the cell.

TL;DR: It is reported that cortical muscarinic sites to which [3H]PZ binds with high affinity are modulated by ions but not guanine nucleotides, suggesting that M1 sites may be independent of a Guanine regulatory protein.

TL;DR: It is suggested that amphetamine-stimulated release of dopamine in nucleus accumbens can increase the incentive value of neutral stimuli with which it is paired, and functional differentiation between different parts of the dopaminergic terminal system is suggested.

TL;DR: A generalized and marked decrease in the lymphocyte mitogenic activity among the depressive group is observed, which may be indicative of an impairment in cell-mediated immunity in patients with primary depressive illness.

TL;DR: In this paper, the binding sites in rat cardiac membranes are saturable, with high affinity, specific GABA-independent and correspond to the peripheral type of benzodiazepine, and the order of potency of displacing agents was: PK 11195 greater than RO5-4864 greater than dipyridamole greater than diazepam greater than clonazepam.

TL;DR: Repetitious opening and closing of the mouth and high frequency clonic jaw movements were observed in rats challenged with dopamine agonists after acute treatment with sulpiride or a low dose of spiroperidol, evidence suggesting D1 dopamine receptor mediation.

TL;DR: Modulation of beta adrenergic and 5HT2 receptors by ovarian hormones might be relevant to hormone-linked affective changes such as premenstrual tension and post-partum depression.

TL;DR: Staining in normal bovine endocrine tissues showed that chromogranin may have a widespread, though as yet undefined, role in the neuroendocrine secretory process.

TL;DR: Cisplatin nephrotoxicity is stereospecific to the cis and not the trans isomer, indicating that the platinum atom is not the proximate neph rotoxicant.

TL;DR: Aluminum ion is bound to at least one of the two specific iron binding sites of serum transferrin and also to serum albumin, as shown by in vivo competition studies with 67-Ga, gel filtration chromatography and ultraviolet difference spectroscopy.

TL;DR: Capsaicin (20-80 mg/kg, s.c.) reduced the inflammatory response to inoculation with Mycobacterium butyricum in the rat and attenuated the increase in substance P content in sciatic nerve, saphenous nerve, dorsal root ganglia, dorsal roots, and dorsal spinal cord which occurs in rats with adjuvant arthritis.

TL;DR: The results suggest that the slow development of depolarization inactivation of DA cells produced by CHAL may contribute to the delayed onset of the clinical effects of long-term treatment with antipsychotic drugs.

TL;DR: The results are consistent with previous reports of the low binding affinity of morphine congeners that lack a free phenolic 3-hydroxyl group and support the view that heroin is a prodrug which serves to determine the distribution of its intrinsically active metabolites, 6-acetylmorphine and morphine.

TL;DR: By coupling this biochemical approach with techniques to study the receptor organization, greater detail concerning the transmitter and cotransmitter interactions among the various neuromodulators can be obtained.

TL;DR: Present evidence strongly implicates monoamines and the endogenous opioid peptides as well as other neuropeptides as playing a role in the central regulation of stress-induced eating.

TL;DR: Keoxifene (LY156758) is a new benzothiophene-derived antiestrogen with an extremely low degree of estrogenicity that inhibited the growth of 7, 12-dimethylbenzanthracene-induced mammary tumors in rats.

TL;DR: The direct demonstration of beta 2 adrenergic receptors in the human heart, with a higher proportion in the right atrium agrees with pharmacologic data and supports the notion that chronotropic effects of adrenergic agonists in man may be mediated by both beta 1 and beta 2 Adrenergic receptors.

TL;DR: In intact animals, immunoreactive melatonin values in both organs exhibited a 24h rhythm with peak levels being measured at 0800h, 2 hours after lights on, and Pinealectomy significantly increased peak levels at0800h in both the retina and the Harderian gland.

TL;DR: The autoradiographic distribution of mu and delta opiate receptors in rat brain is characterized using [3H]-Tyr-D-Ala-Gly-NMe-Phe-gly-ol (DAGO) and [3h]D-Thr2, Thr6leu-enkephalin (DTLET), two highly selective ligands for mu andDelta opiate receptor subtypes, respectively.

TL;DR: It was found that when rat atrial extracts are subjected to reverse phase-high pressure liquid chromatography, diuretic and natriuretic activities are recovered in four distinct chromatographic regions.

TL;DR: The possible topography of the picrotoxinin site and its relationship to convulsant/depressant drug action at the benzodiazepine-GABA receptor-ionophore complex is discussed.

TL;DR: The association of changes in hippocampus and amygdala with negative symptoms of schizophrenia suggests a separate mechanism underlying these symptoms.

TL;DR: The diffusion of most peptides across the brain vascular endothelium seems to be severely restricted, but there are, however, several alternative routes for peripheral peptides to act on the central nervous system.