C
Christian Rosker
Researcher at University of Graz
Publications - 16
Citations - 894
Christian Rosker is an academic researcher from University of Graz. The author has contributed to research in topics: Transient receptor potential channel & TRPC3. The author has an hindex of 12, co-authored 16 publications receiving 843 citations. Previous affiliations of Christian Rosker include University of Cambridge & University of Bern.
Papers
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Journal ArticleDOI
TRPC3 and TRPC4 Associate to Form a Redox-sensitive Cation Channel EVIDENCE FOR EXPRESSION OF NATIVE TRPC3-TRPC4 HETEROMERIC CHANNELS IN ENDOTHELIAL CELLS
Michael Poteser,Annarita Graziani,Christian Rosker,Petra Eder,Isabella Derler,Heike Kahr,Michael X. Zhu,Christoph Romanin,Klaus Groschner +8 more
TL;DR: This work proposes TRPC3 and TRPC4 as subunits of native endothelial cation channels that are governed by the cellular redox state and proposes a redox-sensitive TRPC-TRPC4 channel complex.
Journal ArticleDOI
Ca2+ signaling by TRPC3 involves Na+ entry and local coupling to the Na+/Ca2+ exchanger
Christian Rosker,Annarita Graziani,Michael Lukas,Petra Eder,Michael X. Zhu,Christoph Romanin,Klaus Groschner +6 more
TL;DR: Functional and physical interaction of nonselective TRPC cation channels with NCX proteins as a novel principle of TRPC-mediated Ca2+ signaling is suggested.
Journal ArticleDOI
The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Nav1.6 voltage-dependent sodium channel
Christian Rosker,Birgit Lohberger,Doris Hofer,Bibiane Steinecker,Stefan Quasthoff,Wolfgang Schreibmayer +5 more
TL;DR: Evidence is reported on a highly isoform-specific TTX analog that may well turn out to be an invaluable tool in research for the identification of Na(v1.6)-mediated function, but also for therapeutic intervention.
Journal ArticleDOI
Phospholipase C-dependent control of cardiac calcium homeostasis involves a TRPC3-NCX1 signaling complex
Petra Eder,D Probst,Christian Rosker,Michael Poteser,Heimo Wolinski,Sepp D. Kohlwein,Christoph Romanin,Klaus Groschner +7 more
TL;DR: A PLC-dependent recruitment of a TRPC3-NCX1 complex into the plasma membrane as a pivotal mechanism for the control of cardiac Ca2+ homeostasis is suggested.
Book ChapterDOI
Role of TRP channels in oxidative stress.
TL;DR: The data suggest TRPC species serve as a link between cellular redox state and Ca2+ homeostasis, and modulation of these cellularredox sensors may offer unique opportunities for therapeutic interventions.